50700-72-6
Vecuronium Bromide
CAS: 50700-72-6
Molecular Formula: C34H57BrN2O4
50700-72-6 - Names and Identifiers
| Name | Vecuronium Bromide |
| Synonyms | Norcuron 50700-72-6 Vecuronium Bromide (+)-1-(3,17-Diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide (3alpha,5alpha)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-piperidin-1-ylandrostane bromide (2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane (2beta,3alpha,8xi,9xi,14xi,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-piperidin-1-ylandrostane bromide |
| CAS | 50700-72-6 |
| EINECS | 256-723-9 |
| InChI | InChI=1/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25?,26?,27?,28?,29-,30-,31-,32-,33-,34-;/m0./s1 |
50700-72-6 - Physico-chemical Properties
| Molecular Formula | C34H57BrN2O4 |
| Use | Adjunctive drugs for surgical anesthesia |
50700-72-6 - Vecuronium Bromide for Injection
Authoritative Data Verified Data
This product is a sterile freeze-dried product of vecuronium bromide. The content of vecuronium bromide (C34H57BrN204) shall be between 90.0% and 110.0% of the labeled amount.
trait
This product is white or off-white loose substance.
identification
- take about 10mg of this product, add 2ml of water to dissolve, add 1, 2-dichloroethane 1 ml and methyl orange indicator solution 1 drop, shake, separate, acidify the organic layer with sulfuric acid, that is, show red.
- take about 10mg of this product, add 10ml of water to dissolve, add silver nitrate test solution Dropwise, which generates light yellow curd-like precipitate, which can be separated and slightly soluble in ammonia test solution, but it is almost insoluble in nitric acid.
examination
- the clarity of the solution take 5 bottles of this product, each add water lml,2 minutes should be dissolved, 10 minutes should be clarified.
- acidity: take this product and add water to dissolve it to make a solution containing vecuronium bromide 4mg per lml, which is measured according to law (General rule 0631). The pH value should be 3.8~4.2.
- loss on drying: take about 0.15g of this product (the relative humidity of the weighing sample environment shall not exceed 40%), and dry at 105 ° C for 4 hours, and the weight loss shall not exceed 4.0% (General rule 0831). The content uniformity of
- shall be calculated based on the content of each bottle measured under the content determination item, and shall comply with the regulations (General rule 0941).
- bacterial endotoxin take 1 bottle of this product, add 1 ml of bacterial endotoxin test water to dissolve, use Tris (hydroxymethyl) aminomethane hydrochloride buffer (pH 7.2)(take Tris (hydroxymethyl) aminomethane hydrochloride 15.8g, add appropriate amount of bacterial endotoxin test water to dissolve and dilute to 100ml, shake well, as solution I; Take Tris 1.2g, add appropriate amount of bacterial endotoxin test water to dissolve and dilute to 10ml, shake well as solution II. Take solution I 100ml and solution II 10ml, add bacterial endotoxin test water to 550ml shake, with 0.1 mol/L hydrochloric acid solution or 0. The pH of the 1 mol/L sodium hydroxide solution was adjusted to 7.2, and the solution was sub-packed with pyrogen-free infusion bottles, and sterilized at 121 ° C. For 15 minutes after plugging the gland.) Appropriate dilution, check according to law (General rule 1143), the amount of endotoxin in vecuronium bromide per lm g should be less than 4.0EU.
- sterile take 20 bottles of this product, respectively, and add sterile water to dissolve the solution containing vecuronium bromide 2mg per lml, and check according to law (General rule 1101), should comply with the provisions.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler, methanol-gasified ammonium solution (1.6g of ammonium chloride and 8ml of concentrated ammonia solution), add 0.25mol/L perchloric acid solution to dissolve and dilute to 200ml, mix well)(800:200) as mobile phase; The detection wavelength is 210nm. The number of theoretical plates shall not be less than 3000 calculated by vecuronium bromide peak, and the separation degree between vecuronium bromide peak and adjacent impurity peaks shall meet the requirements.
- determination method take 10 bottles of this product, respectively, precision plus 0.Olmol/L hydrochloric acid solution 2ml, ultrasound to dissolve vecuronium bromide, respectively, take the precise amount of 10 u1, injection of human liquid chromatography, record chromatogram; Another vecuronium bromide reference substance, add 0.Olmol/L hydrochloric acid solution is dissolved and quantitatively diluted to prepare a solution containing about 2mg per 1 ml, which is determined by the same method. The content of each bottle is calculated by the peak area according to the external standard method, and the average content of 10 bottles is obtained.
category
muscle relaxant.
specification
4mg
storage
sealed and stored in a cool place.
Last Update：2024-01-02 23:10:35
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50700-72-6
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