5-hydroxy-4-naphthoquinone
5-Hydroxy-p-naphthoquinone
CAS: 481-39-0
Molecular Formula: C10H6O3
5-hydroxy-4-naphthoquinone - Names and Identifiers
5-hydroxy-4-naphthoquinone - Physico-chemical Properties
| Molecular Formula | C10H6O3 |
| Molar Mass | 174.15 |
| Density | 1.2346 (rough estimate) |
| Melting Point | 161-163 °C (lit.) |
| Boling Point | 265.11°C (rough estimate) |
| Flash Point | 201.3°C |
| Water Solubility | SOLUBLE IN HOT WATER |
| Solubility | Easily soluble in chloroform and benzene, soluble in alcohol and ether, purple-red in alkali solution, slightly soluble in hot water. It can be sublimated and volatilized with water vapor. |
| Vapor Presure | 1.67E-06mmHg at 25°C |
| Appearance | Yellow needle crystal |
| Color | Orange to brown |
| Merck | 14,5269 |
| BRN | 1909764 |
| pKa | 6.59±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.5036 (estimate) |
| MDL | MFCD00001684 |
| Physical and Chemical Properties | Yellow needle-like crystals. Melting point 155 °c. Soluble in chloroform, benzene, soluble in alcohol, ether, soluble in alkali solution was purple, slightly soluble in hot water. Can be sublimated, can be volatilized with water vapor. |
5-hydroxy-4-naphthoquinone - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S28A - |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | QJ5775000 |
| HS Code | 29146990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 112mg/kg |
5-hydroxy-4-naphthoquinone - Reference
| Reference Show more | 1. Zhang Lihua, Li Yan, Zhang Pei, etc. Effects of drying methods on juglone content and antibacterial activity of walnut green husk [J]. Science and Technology of food industry, 2017, 38(10):141-145. 2. Zhou, Lin, et al. "Knock down of LMW-PTP losses stress resistance in Caenorhabditis elegans." International journal of biological macromoles 113 (2018): 1015-1023.https:// doi.org/10.1016/j. Ijbiomac. [IF = 6.953] Lin Zhou et al. "Knock down of LMW-PTP losses stress resistance in Caenorhabditis elegans." Int J Biol Macromol. 2018 Jul;113:1015 4. [IF=4.411] Fang Sheng et al."The Analysis of Phenolic Compounds in Walnut Husk and Pellicle by UPLC-Q-Orbitrap HRMS and HPLC."Molecules. 2021 Jan;26(10):3013 5. [IF=3.943] Yongzhi Hua et al."Juglone regulates gut microbiota and Th17/Treg balance in DSS-induced ulcerative colitis."Int Immunopharmacol. 2021 Aug;97:107683 6. [IF=3.512] Yahong Chen et al."Identification of Potential Human Ryanodine Receptor 1 Agonists and Molecular Mechanisms of Natural Small-Molecule Phenols as Anxiolytics."Acs Omega. 2021;XXXX(XXX):XXX-XXX 7. [IF=5.81] Yihui Yin et al.The Molecular Mechanism of Antioxidation of Huolisu Oral Liquid Based on Serum Analysis and Network Analysis.Front Pharmacol. 2021 Nov 1;12:710976 |
5-hydroxy-4-naphthoquinone - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Juglone is a yellow dye found in black walnut Juglans regia and has antibacterial ability. |
| use | juglone has hemostatic and antibacterial activities, and has also been used to treat eczema, cowhide and tinea. As a pH indicator. dyes and pigments; Fragrance raw materials; pH indicator; Hemostatic agents for medicine and drugs for psoriasis. |
| Production method | Juglone is present as a glycoside of hydrogenated Juglone (trihydroxynaphthalene) in the Juglans family plant Juglans and its same genus black walnut In the immature exocarp (green peel). It can be separated from natural substances or chemically synthesized. |
Last Update：2024-04-09 20:52:54
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