5-fluoroquinolin-8-ol
4-Amino-3-(trifluoromethyl)pyridine
CAS: 387824-61-5
Molecular Formula: C6H5F3N2
5-fluoroquinolin-8-ol - Names and Identifiers
| Name | 4-Amino-3-(trifluoromethyl)pyridine |
| Synonyms | 5-fluoroquinolin-8-ol 3-Trifluoromethyl-4-pyridinamine 3-(Tri?uoromethyl)pyridin-4-amine 3-(trifluoromethyl)pyridin-4-amine 4-Amino-3-(trifluoromethyl)pyridine 3-trifluoromethyl-pyridin-4-ylamine 4-AMINO-3-(TRIFLUOROMETHYL)PYRIDINE 4-Pyridinamine, 3-(trifluoromethyl)- |
| CAS | 387824-61-5 |
| EINECS | 636-786-2 |
| InChI | InChI=1/C6H5F3N2/c7-6(8,9)4-3-11-2-1-5(4)10/h1-3H,(H2,10,11) |
5-fluoroquinolin-8-ol - Physico-chemical Properties
| Molecular Formula | C6H5F3N2 |
| Molar Mass | 162.11 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Melting Point | 98-102 °C |
| Boling Point | 243.0±35.0 °C(Predicted) |
| Flash Point | 100.762°C |
| Vapor Presure | 0.033mmHg at 25°C |
| pKa | 6.87±0.12(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.479 |
| MDL | MFCD02183554 |
5-fluoroquinolin-8-ol - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R25 - Toxic if swallowed R34 - Causes burns R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
5-fluoroquinolin-8-ol - Introduction
4-Amino-3-(trifluoromethyl)pyridine is an organic compound with the chemical formula C6H5F3N2. Its nature is as follows:
1. Appearance: 4-Amino-3-(trifluoromethyl)pyridine is colorless to light yellow crystal or powder.
2. Solubility: It is soluble in most organic solvents, such as ethanol, chloroform and dimethylformamide, and almost insoluble in water.
3. Stability: The compound has good chemical stability and is not sensitive to light, heat and oxygen.
4-Amino-3-(trifluoromethyl)pyridine has many applications in chemistry and medicine:
1. As an important intermediate in chemical synthesis, it is used in the synthesis of various organic compounds, such as pesticides, drugs and dyes.
2. In pesticide research, it can be used to synthesize pesticides with insecticidal and acaricidal effects.
3. In drug research and development, it can be used to synthesize drugs with antiviral, anti-tumor and immunomodulatory effects.
4. in scientific research experiments, it can be used as dyeing reagent, catalyst, etc.
In terms of preparation, 4-Amino-3-(trifluoromethyl)pyridine can be synthesized by the following steps:
1. First, pyridine is reacted with ammonium trifluoroformate to produce 3-(trifluoromethyl) pyridine.
2. Then, by reacting 3-(trifluoromethyl)pyridine with ammonia under basic conditions, 4-Amino-3-(trifluoromethyl)pyridine is generated.
When using and storing 4-Amino-3-(trifluoromethyl)pyridine, you need to pay attention to the following safety information:
1. The compound may be irritating to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment, such as goggles, gloves and protective masks.
2. avoid inhaling its dust or solution, so as not to cause respiratory tract irritation or damage, such as not adapt to immediately stop contact and seek medical attention.
3. storage should be sealed, and away from high temperature and fire.
4. Please follow the normal laboratory operation and waste disposal procedures for use and disposal to ensure safety and environmental protection.
1. Appearance: 4-Amino-3-(trifluoromethyl)pyridine is colorless to light yellow crystal or powder.
2. Solubility: It is soluble in most organic solvents, such as ethanol, chloroform and dimethylformamide, and almost insoluble in water.
3. Stability: The compound has good chemical stability and is not sensitive to light, heat and oxygen.
4-Amino-3-(trifluoromethyl)pyridine has many applications in chemistry and medicine:
1. As an important intermediate in chemical synthesis, it is used in the synthesis of various organic compounds, such as pesticides, drugs and dyes.
2. In pesticide research, it can be used to synthesize pesticides with insecticidal and acaricidal effects.
3. In drug research and development, it can be used to synthesize drugs with antiviral, anti-tumor and immunomodulatory effects.
4. in scientific research experiments, it can be used as dyeing reagent, catalyst, etc.
In terms of preparation, 4-Amino-3-(trifluoromethyl)pyridine can be synthesized by the following steps:
1. First, pyridine is reacted with ammonium trifluoroformate to produce 3-(trifluoromethyl) pyridine.
2. Then, by reacting 3-(trifluoromethyl)pyridine with ammonia under basic conditions, 4-Amino-3-(trifluoromethyl)pyridine is generated.
When using and storing 4-Amino-3-(trifluoromethyl)pyridine, you need to pay attention to the following safety information:
1. The compound may be irritating to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment, such as goggles, gloves and protective masks.
2. avoid inhaling its dust or solution, so as not to cause respiratory tract irritation or damage, such as not adapt to immediately stop contact and seek medical attention.
3. storage should be sealed, and away from high temperature and fire.
4. Please follow the normal laboratory operation and waste disposal procedures for use and disposal to ensure safety and environmental protection.
Last Update：2024-04-09 21:50:46
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CAS: 387824-61-5
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View History
5-fluoroquinolin-8-ol
142335-64-6
115913-32-1
甘油三醋酸酯
Dichloro(mesitylene)ruthenium(II) dimer
软毛青霉酸
4-苯偶氮苯胺
合成薰衣草油
硫酸亚铈(III)
1613026-24-6
142335-64-6
115913-32-1
甘油三醋酸酯
Dichloro(mesitylene)ruthenium(II) dimer
软毛青霉酸
4-苯偶氮苯胺
合成薰衣草油
硫酸亚铈(III)
1613026-24-6