486422-59-7
[4-(dimethylsulfamoyl)phenyl]boronic acid
CAS: 486422-59-7
Molecular Formula: C8H12BNO4S
486422-59-7 - Names and Identifiers
| Name | [4-(dimethylsulfamoyl)phenyl]boronic acid |
| Synonyms | N,N-DIMETHYL 4-BORONOBENZENESULFONAMIDE 4-Borono-N,N-dimethylbenzenesulphonamide [4-(diMethylsulfaMoyl)phenyl]boronic acid [4-(dimethylsulfamoyl)phenyl]boronic acid 4-(N,N-Dimethylsulphonamido)benzeneboronic acid 4-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID [4-[(DIMETHYLAMINO)SULFONYL]PHENYL]BORONIC ACID Boronic acid, B-[4-[(diMethylaMino)sulfonyl]phenyl]- boronic acid, B-[4-[(dimethylamino)sulfonyl]phenyl]- |
| CAS | 486422-59-7 |
| EINECS | 200-528-9 |
| InChI | InChI=1/C8H12BNO4S/c1-10(2)15(13,14)8-5-3-7(4-6-8)9(11)12/h3-6,11-12H,1-2H3 |
486422-59-7 - Physico-chemical Properties
| Molecular Formula | C8H12BNO4S |
| Molar Mass | 229.06 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 140-144 |
| Boling Point | 410.0±55.0 °C(Predicted) |
| Flash Point | 201.7°C |
| Vapor Presure | 1.86E-07mmHg at 25°C |
| pKa | 7.39±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.579 |
486422-59-7 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Note | Irritant/Keep Cold |
486422-59-7 - Introduction
[4-(dimethylsulfamoyl)phenyl]boronic acid is an organic boron compound with the chemical formula C8H12BNO4S. Its properties are as follows:
1. Appearance: White to light yellow solid.
2. Solubility: Soluble in many organic solvents, such as dimethyl sulfoxide, chloroform and acetonitrile.
3. melting point: about 160-165 ℃.
[4-(dimethylsulfamoyl)phenyl] The main uses of boronic acid are as follows:
1. drug synthesis: as an intermediate of benzimidazole anticancer drugs.
2. Ligands: As organoboron ligands, they form complexes with metals and are widely used in catalytic reactions.
3. chemical biology research: can be used to mediate the interaction between protein and carbohydrate or nucleic acid.
The method for preparing [4-(dimethylsulfamoyl)phenyl]boronic acid is as follows:
Under neutral or alkaline conditions, 4-(N,N-dimethylsulfonamido) benzaldehyde is prepared by reacting 4-bromomethanesulfonylbenzene with dimethylimide. Then, it reacts with triphenylboron to produce the target product [4-(dimethylsulfamoyl)phenyl]boronic acid.
Regarding safety information, the following points should be noted:
1. [4-(dimethylsulfamoyl)phenyl]boronic acid is a chemical and direct contact with skin and eyes should be avoided.
2. During operation, pay attention to prevent inhalation of gas, dust or smoke, and operate in a well-ventilated place.
3. Wear acid and alkali resistant gloves and protective glasses if necessary.
4. in case of contact, rinse immediately with plenty of water and seek medical advice.
5. The compound may be harmful to the environment, should comply with the corresponding waste disposal regulations.
1. Appearance: White to light yellow solid.
2. Solubility: Soluble in many organic solvents, such as dimethyl sulfoxide, chloroform and acetonitrile.
3. melting point: about 160-165 ℃.
[4-(dimethylsulfamoyl)phenyl] The main uses of boronic acid are as follows:
1. drug synthesis: as an intermediate of benzimidazole anticancer drugs.
2. Ligands: As organoboron ligands, they form complexes with metals and are widely used in catalytic reactions.
3. chemical biology research: can be used to mediate the interaction between protein and carbohydrate or nucleic acid.
The method for preparing [4-(dimethylsulfamoyl)phenyl]boronic acid is as follows:
Under neutral or alkaline conditions, 4-(N,N-dimethylsulfonamido) benzaldehyde is prepared by reacting 4-bromomethanesulfonylbenzene with dimethylimide. Then, it reacts with triphenylboron to produce the target product [4-(dimethylsulfamoyl)phenyl]boronic acid.
Regarding safety information, the following points should be noted:
1. [4-(dimethylsulfamoyl)phenyl]boronic acid is a chemical and direct contact with skin and eyes should be avoided.
2. During operation, pay attention to prevent inhalation of gas, dust or smoke, and operate in a well-ventilated place.
3. Wear acid and alkali resistant gloves and protective glasses if necessary.
4. in case of contact, rinse immediately with plenty of water and seek medical advice.
5. The compound may be harmful to the environment, should comply with the corresponding waste disposal regulations.
Last Update：2024-04-09 20:02:46
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View History
486422-59-7
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