484-76-4
OKANIN
CAS: 484-76-4
Molecular Formula: C15H12O6
484-76-4 - Names and Identifiers
484-76-4 - Physico-chemical Properties
| Molecular Formula | C15H12O6 |
| Molar Mass | 288.25 |
| Density | 1.584±0.06 g/cm3(Predicted) |
| Melting Point | 235-242 °C |
| Boling Point | 638.0±55.0 °C(Predicted) |
| Solubility | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Appearance | Solid |
| Color | Dark Orange |
| pKa | 7.22±0.40(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Very Hygroscopic |
| MDL | MFCD00017392 |
484-76-4 - Reference
| Reference Show more | 1. Zhuoicing rain, Wei Shengli, Feng Lagerstroemia, Shi Yan, Ren mi-mi, Zhao Ting, Zhang Yuan. Comparative study on the quality of snow chrysanthemum and its variation types [J]. Journal of Beijing University of Chinese Medicine, 2021,44(01):69-77. 2. Shi, Yurui, et al. "Determination and Pharmaceutics of Okanin Rat Plasma by ultra high Performance Liquid Chromatography Coupled with Triple-Quadrupole Tandem Mass spectroscopy." Journal of analytical methods in chemistry 2020 (2020).https://doi.org/1 3. [IF=2.193] Shi Yurui et al."Determination and Pharmacokinetics of Okanin in Rat Plasma by UltraHigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Tandem Mass Spectrometry."J Anal Methods Chem. 2020;2020:4247128 |
484-76-4 - Introduction
Bioactive Okanin is an active ingredient of Coreopsis tinctoria. Okanin attenuates LPS-induced activation of microglia by inhibiting TLR4/NF-& kappa;B signaling pathway.
Target
TLR4
p65
In vitro study
Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κ B p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells.
Last Update：2024-04-09 20:45:29
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