4-Methylsalicylamide
4-Methylsalicylamide
CAS: 49667-22-3
Molecular Formula: C8H9NO2
4-Methylsalicylamide - Names and Identifiers
| Name | 4-Methylsalicylamide |
| Synonyms | 4-Methylsalicylamide 4-METHYL SALICYLAMIDE 2-HYDROXY-4-METHYLBENZAMIDE 2-hydroxy-4-methylbenzamide Benzamide,2-hydroxy-4-methyl- Benzamide, 2-hydroxy-4-methyl- (9CI) |
| CAS | 49667-22-3 |
| InChI | InChI=1/C8H9NO2/c1-5-2-3-6(8(9)11)7(10)4-5/h2-4,10H,1H3,(H2,9,11) |
4-Methylsalicylamide - Physico-chemical Properties
| Molecular Formula | C8H9NO2 |
| Molar Mass | 151.16 |
| Density | 1.231g/cm3 |
| Boling Point | 299.107°C at 760 mmHg |
| Flash Point | 134.695°C |
| Vapor Presure | 0.001mmHg at 25°C |
| Refractive Index | 1.598 |
4-Methylsalicylamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
4-Methylsalicylamide - Introduction
4-Methylsalicylamide(4-Methylsalicylamide) is an organic compound with the chemical formula C8H9NO2. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4-Methylsalicylamide is a white crystalline solid.
-Solubility: easy to dissolve in alcohol and chloroform, insoluble in water.
-Melting point: about 160-165 degrees Celsius.
Use:
- 4-Methylsalicylamide is commonly used as a pharmaceutical intermediate. It can be used to synthesize various kinds of drugs, such as antipyretic analgesics, anti-inflammatory drugs, etc.
-It can also be used to prepare organic dyes and sometimes used as additives in cosmetics.
Preparation Method:
-The preparation of 4-Methylsalicylamide can generally be obtained by the acylation reaction of methyl salicylic acid. Methyl salicylic acid reacts with anhydrous hydrochloric acid under appropriate conditions to produce methyl 4-methylsalicylate, which reacts with ammonia to produce 4-Methylsalicylamide.
Safety Information:
- 4-Methylsalicylamide is a chemical that requires safety precautions when used.
-It may have an irritating effect on the eyes, skin and respiratory system, so direct contact should be avoided.
-During use or preparation, it is necessary to ensure adequate ventilation and pay attention to avoid inhalation or intake.
-In case of accidental contact or ingestion, the affected area should be cleaned in time and medical help should be sought immediately.
Nature:
-Appearance: 4-Methylsalicylamide is a white crystalline solid.
-Solubility: easy to dissolve in alcohol and chloroform, insoluble in water.
-Melting point: about 160-165 degrees Celsius.
Use:
- 4-Methylsalicylamide is commonly used as a pharmaceutical intermediate. It can be used to synthesize various kinds of drugs, such as antipyretic analgesics, anti-inflammatory drugs, etc.
-It can also be used to prepare organic dyes and sometimes used as additives in cosmetics.
Preparation Method:
-The preparation of 4-Methylsalicylamide can generally be obtained by the acylation reaction of methyl salicylic acid. Methyl salicylic acid reacts with anhydrous hydrochloric acid under appropriate conditions to produce methyl 4-methylsalicylate, which reacts with ammonia to produce 4-Methylsalicylamide.
Safety Information:
- 4-Methylsalicylamide is a chemical that requires safety precautions when used.
-It may have an irritating effect on the eyes, skin and respiratory system, so direct contact should be avoided.
-During use or preparation, it is necessary to ensure adequate ventilation and pay attention to avoid inhalation or intake.
-In case of accidental contact or ingestion, the affected area should be cleaned in time and medical help should be sought immediately.
Last Update：2024-04-09 20:49:11
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