4-Methylimidazole
4-Methylimidazole
CAS: 822-36-6
Molecular Formula: C4H6N2
4-Methylimidazole - Names and Identifiers
| Name | 4-Methylimidazole |
| Synonyms | 4-Me-i NSC 40744 4-Methylimidazole 4-METHYL IMIDAZOLE 4-methyl-1h-imidazol 4-methyl-1H-imidazole 4(5)-Methylglyoxaline 1H-Imidazole,4-methyl 5-methyl-1H-imidazole 1H-Imidazole, 4-methyl- 4(Or 5)-Methylimidazole 4-methyl-1(3)H-imidazole |
| CAS | 822-36-6 |
| EINECS | 212-497-3 |
| InChI | InChI=1/C4H6N2/c1-4-2-5-3-6-4/h2-3H,1H3,(H,5,6) |
| InChIKey | XLSZMDLNRCVEIJ-UHFFFAOYSA-N |
4-Methylimidazole - Physico-chemical Properties
| Molecular Formula | C4H6N2 |
| Molar Mass | 82.1 |
| Density | 1.02 |
| Melting Point | 44-47°C(lit.) |
| Boling Point | 263°C(lit.) |
| Flash Point | >230°F |
| Water Solubility | Soluble in water. |
| Solubility | Easily soluble in water, ethanol and general solvents, hardly soluble in ether. |
| Vapor Presure | 0.0172mmHg at 25°C |
| Appearance | Slightly yellow solid |
| Color | Reddish-brown to green to brown |
| BRN | 1453 |
| pKa | pK1:7.55(＋1) (25°C) |
| Storage Condition | 2-8°C |
| Sensitive | Easy to absorb moisture and sensitive to air |
| Refractive Index | 1.5037 |
| MDL | MFCD00005201 |
| Physical and Chemical Properties | Density 1.02 melting point 46-48°C boiling point 263°C flash point 157°C |
| Use | Used as the curing agent of epoxy resin, the main raw material of drug cimetidine, can also be used for the synthesis of antibacterial agents |
4-Methylimidazole - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R21/22 - Harmful in contact with skin and if swallowed. R34 - Causes burns R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes. |
| UN IDs | UN 3263 8/PG 3 |
| WGK Germany | 2 |
| RTECS | NI7350000 |
| TSCA | Yes |
| HS Code | 29339900 |
| Hazard Class | 8 |
| Packing Group | III |
4-Methylimidazole - Upstream Downstream Industry
| Raw Materials | Methylglyoxal oxalic acid diammonium salt Ammonia Methyl alcohol Formaldehyde |
| Downstream Products | N-Cyano-N-[2-(5-methylimidazole-4-methylthio)ethyl]-S-methyl isothiourea cimetidine |
4-Methylimidazole - Reference
| Reference Show more | 1. Qaraah, Fahim A., et al. "Facile route for C–N/Nb 2 O 5 nanonet synthesis based on 2-methylimidazole for visible-light driven photocatalytic degradation of Rhodamine B." RSC Advances 9.68 (2019): 39561-39571.https://doi.org/10.1039/C9RA07505D |
4-Methylimidazole - Nature
Open Data Verified Data
white or off-white crystals. The melting point was 54-56 °c. Boiling point 263 °c. Flash point 157 °c. The density was 1. 02~1.06g/mL. Soluble in water, ethanol.
Last Update：2025-06-10 22:55:16
4-Methylimidazole - Preparation Method
Open Data Verified Data
results from the reaction of methylglyoxal, acetaldehyde and ammonia.
Last Update：2022-01-01 10:57:14
4-Methylimidazole - Introduction
Soluble in water and ethanol. It's corrosive.
Last Update：2022-10-16 17:29:08
4-Methylimidazole - Application
Open Data Verified Data
used as the curing agent of epoxy resin, the main raw material of drug cimetidine, can also be used for the synthesis of antibacterial agents.
Last Update：2025-08-19 16:24:40
4-Methylimidazole - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2B (Vol. 101) 2013 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | pharmaceutical intermediates. organic and pharmaceutical synthesis intermediates, is the main intermediate for the synthesis of cimetidine. used as curing agent of epoxy resin; The main raw material of cimetidine; Used in the synthesis of antibacterial agent used as curing agent of epoxy resin, the main raw material of drug cimetidine, can also be used for the synthesis of antibacterial agents such as |
| production method | from the reaction of acetone aldehyde, acetaldehyde and ammonia. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:11:58
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View History
4-Methylimidazole
100-29-8
20261-65-8
2-Chloro-4-nitrophenol
N-ALPHA-CBZ-GLN-GLY
HUNNEMANINE
hexafluoro-pentanedioicaci
215872-46-1
936-02-7
56362-45-9
100-29-8
20261-65-8
2-Chloro-4-nitrophenol
N-ALPHA-CBZ-GLN-GLY
HUNNEMANINE
hexafluoro-pentanedioicaci
215872-46-1
936-02-7
56362-45-9
Raw Materials for 4-Methylimidazole
Downstream Products for 4-Methylimidazole