4-METHYLSULFINYLBUTYLGLUCOSINOLATE
Glucoraphanin
CAS: 21414-41-5
Molecular Formula: C12H23NO10S3
4-METHYLSULFINYLBUTYLGLUCOSINOLATE - Names and Identifiers
4-METHYLSULFINYLBUTYLGLUCOSINOLATE - Physico-chemical Properties
| Molecular Formula | C12H23NO10S3 |
| Molar Mass | 437.51 |
| Density | 1.78±0.1 g/cm3 (20 ºC 760 Torr) |
| Solubility | Soluble in water, methanol, DMSO |
| Appearance | White powder |
| pKa | -2.93±0.18(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD08460269 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from semen raphani. |
| In vivo study | Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2 −/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2 −/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice. |
4-METHYLSULFINYLBUTYLGLUCOSINOLATE - Reference
| Reference Show more | 1. Jiang Rui, Li Hongyan, Xue Changhu. Effects of different treatments on sulforaphane and sulforaphane in semen raphani [J]. Food Science and Technology 2019 v.44;No.337(11):91-97. 2. Zhang Rui, Yu Jianli, Song Xuan, Yan Yuanyuan, Li Chao. Antibacterial activity and in vitro immune activity of sulfatide extract from broccoli and Raphanus sativus [J]. Food Research and Development, 2021,42(04):1-7. |
4-METHYLSULFINYLBUTYLGLUCOSINOLATE - Reference Information
| Introduction | sulforaphane Glucosinolate is an active ingredient of broccoli extract and a prodrug of sulforaphane, sulforaphane Glucosinolates can be converted into sulforaphane in vivo, thereby exerting anti-cancer and anti-oxidation effects. |
| efficacy and function | sulforaphane glucosinolates are a naturally active product mainly found in Broccoli seeds and shoots, after the action of myrosinase or intestinal microorganisms can be converted into Sulforaphane (Sulforaphane). Sulforaphane is one of the most potent activators of Nrf2, which can activate Nrf2 to activate detoxification, antioxidant, anti-inflammatory and other cell protective effects. |
| biological activity | Glucoraphanin is glucosinolates present in cruciferous vegetables and is a precursor of the Nrf2 inducer sulforaphane, the latter has antioxidant, anti-inflammatory, anti-cancer effects. |
| Use | Anti-cancer antioxidant. for content determination/identification/pharmacological experiments. |
Last Update：2024-04-09 21:01:54
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Mobile: +86-18621343501
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View History
4-METHYLSULFINYLBUTYLGLUCOSINOLATE
CEPHRADINE HYDRATE
copper(2++)salt
p-fluorophenol
DL-alpha-Phenylethylamine
EMC Violet RL 10
APD 356
BETA-2-NAPHTHONITRILE
Busan 85
CEPHRADINE HYDRATE
copper(2++)salt
p-fluorophenol
DL-alpha-Phenylethylamine
EMC Violet RL 10
APD 356
BETA-2-NAPHTHONITRILE
Busan 85