4-Bromomethylene-piper
1-Piperidinecarboxylicacid, 4-(bromomethylene)-, 1,1-dimethylethyl ester
CAS: 1020329-80-9
Molecular Formula: C11H18BrNO2
4-Bromomethylene-piper - Names and Identifiers
4-Bromomethylene-piper - Physico-chemical Properties
| Molecular Formula | C11H18BrNO2 |
| Molar Mass | 276.17 |
| Density | 1.390 |
| Boling Point | 317.7±35.0 °C(Predicted) |
| Flash Point | 145.932 °C |
| pKa | -1.51±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD01632525 |
4-Bromomethylene-piper - Introduction
1-N-tert-butoxycarbonyl-4-(bromomethylene) piperidine, also known as Boc-4-(bromomethylene) piperidine, has the following properties:
1. Appearance: colorless to light yellow crystal or powder.
2. molecular formula: C12H20BrNO3.
3. Molecular weight: 303.20g/mol.
4. melting point: about 75-80 ℃.
5. Solubility: Soluble in ethanol, chloroform, dichloromethane and other organic solvents.
The main uses of this compound include:
1. organic synthesis: as an intermediate in organic synthesis, it can be used to synthesize various drugs, pesticides and other organic compounds.
2. Chemical reagent: It can be used as protecting group or esterification reagent in organic synthesis reaction.
Preparation Method:
The preparation method of 1-N-tert-butoxycarbonyl-4-(bromomethylene) piperidine is as follows:
1. First, 4-(bromomethylene) piperidine is reacted with trifluoroacetic anhydride under an inert atmosphere to produce 4-(bromomethylene) piperidinoyl trifluoroacetic anhydride.
2. Next, the resulting anhydride is reacted with anetholyl ester under basic conditions to produce 1-N-tert-butoxycarbonyl-4-(bromomethylene) piperidine.
Safety Information:
Regarding the safety information of this compound, the following points need to be noted:
1. The compound is an organic bromide, which is irritating to skin, eyes and mucous membranes. Please avoid contact with it.
2. during the operation should wear appropriate protective gloves, glasses and masks, and maintain good ventilation conditions.
3. Please keep it away from fire and oxidant to prevent fire and explosion.
4. Inhalation or ingestion is strictly prohibited. If you accidentally inhale or ingest, please seek medical attention immediately.
1. Appearance: colorless to light yellow crystal or powder.
2. molecular formula: C12H20BrNO3.
3. Molecular weight: 303.20g/mol.
4. melting point: about 75-80 ℃.
5. Solubility: Soluble in ethanol, chloroform, dichloromethane and other organic solvents.
The main uses of this compound include:
1. organic synthesis: as an intermediate in organic synthesis, it can be used to synthesize various drugs, pesticides and other organic compounds.
2. Chemical reagent: It can be used as protecting group or esterification reagent in organic synthesis reaction.
Preparation Method:
The preparation method of 1-N-tert-butoxycarbonyl-4-(bromomethylene) piperidine is as follows:
1. First, 4-(bromomethylene) piperidine is reacted with trifluoroacetic anhydride under an inert atmosphere to produce 4-(bromomethylene) piperidinoyl trifluoroacetic anhydride.
2. Next, the resulting anhydride is reacted with anetholyl ester under basic conditions to produce 1-N-tert-butoxycarbonyl-4-(bromomethylene) piperidine.
Safety Information:
Regarding the safety information of this compound, the following points need to be noted:
1. The compound is an organic bromide, which is irritating to skin, eyes and mucous membranes. Please avoid contact with it.
2. during the operation should wear appropriate protective gloves, glasses and masks, and maintain good ventilation conditions.
3. Please keep it away from fire and oxidant to prevent fire and explosion.
4. Inhalation or ingestion is strictly prohibited. If you accidentally inhale or ingest, please seek medical attention immediately.
Last Update：2024-04-09 21:21:28
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View History
4-Bromomethylene-piper
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dihexyllead
依匹斯汀盐酸盐
98021-95-5
枸橼酸莫沙比利
acidpotassiumsulfate
2634687-74-2
kyselina2-hydroxyethansulfonova
2-碘酰苯甲酸
1804379-42-7
dihexyllead
依匹斯汀盐酸盐
98021-95-5
枸橼酸莫沙比利
acidpotassiumsulfate