4-Bromo-2,3-Difluoroanisole
4-Bromo-2,3-Difluoroanisole
CAS: 406482-22-2
Molecular Formula: C7H5BrF2O
4-Bromo-2,3-Difluoroanisole - Names and Identifiers
| Name | 4-Bromo-2,3-Difluoroanisole |
| Synonyms | 2,3-Difluoro-4-bromoanisole 4-Bromo-2,3-Difluoroanisole 4-Bromo-2,3-difluoroanisole 1-Bromo-2,3-difluoro-4-methoxybenzene 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE 4-Bromo-2,3-difluorophenyl methyl ether Benzene, 1-bromo-2,3-difluoro-4-methoxy- benzene, 1-bromo-2,3-difluoro-4-methoxy- |
| CAS | 406482-22-2 |
| InChI | InChI=1/C7H5BrF2O/c1-11-5-3-2-4(8)6(9)7(5)10/h2-3H,1H3 |
4-Bromo-2,3-Difluoroanisole - Physico-chemical Properties
| Molecular Formula | C7H5BrF2O |
| Molar Mass | 223.01 |
| Density | 1.615 |
| Boling Point | 203.2±35.0 °C(Predicted) |
| Flash Point | 91.1°C |
| Vapor Presure | 0.4mmHg at 25°C |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5 |
4-Bromo-2,3-Difluoroanisole - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Note | Irritant |
4-Bromo-2,3-Difluoroanisole - Introduction
4-Bromo-2,3-Difluoroanisole is an organic compound with the formula BrC6H3(F)2OCH3. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4-Bromo-2,3-Difluoroanisole is a colorless to slightly yellow liquid.
-Solubility: It can be dissolved in common organic solvents such as ethanol, ether and dimethylformamide.
Use:
- 4-Bromo-2,3-Difluoroanisole is commonly used in arylation reactions in organic synthesis and can be used as a derivative of aromatic ethers.
-It can also be used as a pharmaceutical and pesticide intermediate for the synthesis of other organic compounds.
Preparation Method:
- 4-Bromo-2,3-Difluoroanisole can be synthesized by bromination and fluorination of p-hydroxybenzoic acid.
-Synthesis steps:
1. p-hydroxybenzoic acid is reacted with bromine and a fluorinating agent to obtain 4-bromo-2, 3-difluorobenzoic acid.
2. The obtained 4-bromo-2, 3-difluorobenzoic acid is reacted with methanol to generate 4-Bromo-2,3-Difluoroanisole by condensation reaction.
Safety Information:
- 4-Bromo-2,3-Difluoroanisole may be irritating to humans and care should be taken to prevent contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves and masks, during use and handling.
-The compound should be used in a well-ventilated place to avoid inhaling its vapors.
-Seek medical help if ingested or inhaled.
Nature:
-Appearance: 4-Bromo-2,3-Difluoroanisole is a colorless to slightly yellow liquid.
-Solubility: It can be dissolved in common organic solvents such as ethanol, ether and dimethylformamide.
Use:
- 4-Bromo-2,3-Difluoroanisole is commonly used in arylation reactions in organic synthesis and can be used as a derivative of aromatic ethers.
-It can also be used as a pharmaceutical and pesticide intermediate for the synthesis of other organic compounds.
Preparation Method:
- 4-Bromo-2,3-Difluoroanisole can be synthesized by bromination and fluorination of p-hydroxybenzoic acid.
-Synthesis steps:
1. p-hydroxybenzoic acid is reacted with bromine and a fluorinating agent to obtain 4-bromo-2, 3-difluorobenzoic acid.
2. The obtained 4-bromo-2, 3-difluorobenzoic acid is reacted with methanol to generate 4-Bromo-2,3-Difluoroanisole by condensation reaction.
Safety Information:
- 4-Bromo-2,3-Difluoroanisole may be irritating to humans and care should be taken to prevent contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves and masks, during use and handling.
-The compound should be used in a well-ventilated place to avoid inhaling its vapors.
-Seek medical help if ingested or inhaled.
Last Update：2024-04-09 15:17:57
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View History
4-Bromo-2,3-Difluoroanisole
Cyanopropyl Dimethyl Dimethylamino Silane
Pyridine, 3-fluoro-2-iodo-
2-methyl-2-(thiomorpholin-4-yl)propan-1-amine dihydrochloride
methyl 2-bromo-4-(bromomethyl)benzoate
Cyanopropyl Dimethyl Dimethylamino Silane
Pyridine, 3-fluoro-2-iodo-
2-methyl-2-(thiomorpholin-4-yl)propan-1-amine dihydrochloride
methyl 2-bromo-4-(bromomethyl)benzoate