4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE
2-Amino-4-(trifluoromethyl)pyridine
CAS: 106447-97-6
Molecular Formula: C6H5F3N2
4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE - Names and Identifiers
4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE - Physico-chemical Properties
| Molecular Formula | C6H5F3N2 |
| Molar Mass | 162.11 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Melting Point | 70-74°C |
| Boling Point | 221.3±40.0 °C(Predicted) |
| Flash Point | 87.662°C |
| Vapor Presure | 0.108mmHg at 25°C |
| Appearance | Powder, Solid or Crystalline |
| Color | White to pale brown |
| BRN | 7869677 |
| pKa | 4.55±0.11(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.479 |
| Physical and Chemical Properties | White-like crystal |
4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R34 - Causes burns R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
| Packing Group | II |
4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE - Reference Information
| application | 2-amino -4-trifluoromethylpyridine is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in the laboratory research and development process and the chemical and pharmaceutical synthesis process. 2-amino-substituted nitrogen-containing six-membed heterocyclic compounds have important applications in the field of chemical industry, especially 2-aminopyridine and its derivatives are one of the important structures in the molecules of drugs and agrochemicals, which are widely used in the synthesis of natural products, drugs, luminescent materials and various fine chemicals. 2-Amino-4-trifluoromethylpyridine is a 2-amino-substituted nitrogen-containing six-membed heterocyclic compound. It is an important pharmaceutical intermediate and can be prepared by the reaction of 2-fluoro-4-trifluoromethylpyridine with ethylene-alkylpyridine hydrochloride. |
| preparation | preparation of 4-trifluoromethyl -2-amino-pyridine: adding 2-fluoro -4-trifluoromethyl-pyridine (1mmolg), acetoethylenehydrochloride (1.2mmol,113.4mg),NaOH(2.5mmol,100mg), h2O (0.5mL) and dimethyl sulfoxide (2.5mL). The reaction was carried out at 130 ℃ for 24 hours. After the reaction was completed, it was cooled to room temperature. 10mL of ethyl acetate was added to quench the reaction, 6mL of saturated salt water was added to wash, the organic phase was separated, the aqueous phase was extracted with ethyl acetate three times (the dosage of ethyl acetate was 6mL each time) and the organic phase was combined, anhydrous sodium sulfate was added to dry, and the solvent including organic solvent and inorganic solvent was removed by vacuum distillation. The organic solvent was separated by column chromatography to obtain the target product 4-trifluoromethyl-2-aminopyridine with a yield of 61%. |
| chemical properties | white-like crystals |
Last Update：2024-04-10 22:40:09
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View History
4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE
茴香酸对羟基苯乙酯
3-chlorobenzene-1-thiol
大蒜精油(大蒜提取物)
3-Chloro-2-fluoroboronic acid
Butanedioic acid, bis(2-methylpropyl) ester
茴香酸对羟基苯乙酯
3-chlorobenzene-1-thiol
大蒜精油(大蒜提取物)
3-Chloro-2-fluoroboronic acid
Butanedioic acid, bis(2-methylpropyl) ester