4,4-DifluoropiperidineHCl
4,4-Difluoropiperidine hydrochloride
CAS: 144230-52-4
Molecular Formula: C5H10ClF2N
4,4-DifluoropiperidineHCl - Names and Identifiers
| Name | 4,4-Difluoropiperidine hydrochloride |
| Synonyms | 4,4-DifluoropiperidineHCl 4,4-difluoropiperidin-1-ium 4,4-Difluoropiperidine hy... 4,4-Difluoropiperidine hydrochloride 4,4-DIFLUOROPIPERIDINE HYDROCHLORIDE 4,4-Difluoropiperidine hydrochloride fandachem |
| CAS | 144230-52-4 |
| EINECS | 604-401-7 |
| InChI | InChI=1/C9H8F2O2/c1-2-13-9(12)6-3-4-7(10)8(11)5-6/h3-5H,2H2,1H3 |
| InChIKey | OABUKBBBSMNNPM-UHFFFAOYSA-N |
4,4-DifluoropiperidineHCl - Physico-chemical Properties
| Molecular Formula | C5H10ClF2N |
| Molar Mass | 157.59 |
| Density | 1.222g/cm3 |
| Melting Point | 173-177°C |
| Boling Point | 223.4°C at 760 mmHg |
| Flash Point | 86.6°C |
| Vapor Presure | 0.0964mmHg at 25°C |
| BRN | 6812163 |
| Storage Condition | 2-8°C |
| Sensitive | Hygroscopic |
| Refractive Index | 1.472 |
| MDL | MFCD03095381 |
4,4-DifluoropiperidineHCl - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
4,4-DifluoropiperidineHCl - Reference Information
| use | 4, 4-dihaloperidol hydrochloride is a piperidine derivative, which is in great demand as a pharmaceutical intermediate. It is also an important fragment of a novel histamine -3 receptor antagonist. |
| preparation method | 20Kg dichloromethane is added to 50 l dry four-mouth bottle at one time, then 2Kg A1 is added at one time, the internal temperature is 25 ℃ at this time, the adding time is 10 minutes, the internal temperature is unchanged during the adding process, then the temperature is reduced to 15-20 ℃, the reaction system is replaced with argon gas. 2.2Kg trifluoro-thio-morpholine is added by dropping method for 240 minutes. the feeding process is exothermic but relatively gentle. the internal temperature is kept below 30 ℃, and then 10 h is stirred at 25-30 ℃. the stirring process is easy. The reaction is controlled by TLC (PE: EA = 3:1). ninhydrin is used as developer, which shows that the reaction of raw materials is complete and new product points are generated. GC shows that the product content is 95% and the elimination product content is 2%. |
Last Update：2024-04-09 20:49:11
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View History
4,4-DifluoropiperidineHCl
5-cyano-1-(3-nitrobenzyl)indole
2-硝基-3,4,5-三氟苯甲醚
1,3,3-三甲基二环[2.2.1]庚-2-醇
2,6-dimethylhept-5-en-1-al
2-[3-(benzyloxy)phenyl]-N-methoxy-N-methylacetamide
2-pentenal, (2E)-
2-HYDROXY-3-[4-IMIDAZOYL]-PROPANOIC ACID
5-cyano-1-(3-nitrobenzyl)indole
2-硝基-3,4,5-三氟苯甲醚
1,3,3-三甲基二环[2.2.1]庚-2-醇
2,6-dimethylhept-5-en-1-al
2-[3-(benzyloxy)phenyl]-N-methoxy-N-methylacetamide
2-pentenal, (2E)-
2-HYDROXY-3-[4-IMIDAZOYL]-PROPANOIC ACID