348-54-9
2-fluoroaniline
CAS: 348-54-9
Molecular Formula: C6H6FN
348-54-9 - Names and Identifiers
| Name | 2-fluoroaniline |
| Synonyms | AKOS 91139 2-Fluoranilin FLUOROANILINE-2 o-Fluoroaniline 2-fluoroaniline 2-FLUOROANILINE 2-fluoro-aniline AKOS BBS-00003628 2-fluoro-benzenamin 2-Fluoro-phenylamine 2-fluoro-Benzenamine 1,2-fluorobenzenamine LABOTEST-BB LTBB000714 Benzenamine, 2-fluoro- 1-Amino-2-fluorobenzen 1-AMINO-2-FLUOROBENZENE 1-Amino-2-fluorobenzene |
| CAS | 348-54-9 |
| EINECS | 206-478-9 |
| InChI | InChI=1/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2 |
348-54-9 - Physico-chemical Properties
| Molecular Formula | C6H6FN |
| Molar Mass | 111.12 |
| Density | 1.151g/mLat 25°C(lit.) |
| Melting Point | -29 °C |
| Boling Point | 182-183°C(lit.) |
| Flash Point | 140°F |
| Water Solubility | 17 g/L (20°C) |
| Solubility | 17g/l |
| Vapor Presure | 1 hPa (20 °C) |
| Appearance | Liquid |
| Specific Gravity | 1.151 |
| Color | Clear colorless |
| BRN | 1524219 |
| pKa | 3.2(at 25℃) |
| Storage Condition | Store below +30°C. |
| Refractive Index | n20/D 1.544(lit.) |
| Physical and Chemical Properties | Density 1.151 melting point -29°C boiling point 182-183°C refractive index 1.54-1.542 flash point 60°C |
| Use | Used as pharmaceutical, pesticide and dye intermediates |
348-54-9 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/38 - Irritating to eyes and skin. R33 - Danger of cumulative effects R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 2941 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | BY1390000 |
| TSCA | T |
| HS Code | 29214210 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
348-54-9 - Upstream Downstream Industry
| Raw Materials | 1-Chloro-2-nitrobenzene Potassium fluoride Hydrogen |
348-54-9 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | o-fluoroaniline is a light yellow liquid and oily. The color is not obvious when the amount is small. Slightly aromatic, toxic. It has a stimulating effect on the skin, and its vapor or smoke has a stimulating effect on the eyes, mucous membranes and upper respiratory tract. Entering the human body, it can form cyanosis caused by methemoglobin, which is harmful to the environment. This product is flammable and irritating. O-fluoroaniline is an important intermediate in the synthesis of fluorine-containing medicines and dyes. O-fluoroaniline can be used as an intermediate in pharmaceutical synthesis. |
| application | o-fluoroaniline is an important intermediate for the synthesis of fluorine-containing medicines and dyes. O-fluoroaniline can be used to synthesize heat-sensitive dye FH-102, which is a kind of heat-sensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, cardiac electroencephalogram recording paper, telephone fax paper and transparent thermal film for oil field. |
| Preparation | A method for preparing o-fluoronitrobenzene by hydrogenation of o-fluoronitrobenzene, the method includes the following steps: step 1. loading the catalyst in a fixed bed reactor, At room temperature, nitrogen is introduced into the fixed bed reactor filled with the catalyst to exhaust the air in the fixed bed reactor, then, nitrogen diluted reducing gas is introduced into the fixed bed reactor, and the temperature of the fixed bed reactor is raised to 120 ℃ ~ 280 ℃ at a heating rate of 1 ℃/min ~ 10 ℃/min. The catalyst includes Al2O3 carrier, Pt, metal M1 and metal M2 supported on Al2O3 carrier, and the mass percentage content of Pt in the catalyst is 0.05% ~ 1%, the mass percentage content of metal M1 is 0.05%-3%, and the mass percentage content of metal M2 is 0.01%-3%; The metal M1 is Pd, Sn or Zn; The metal M2 is K, Co, Ga, In, Mn, Ag or Ce; The volume percentage content of reducing gas in reducing gas diluted by nitrogen is 3%-10%; the ratio of the flow rate of the nitrogen-diluted reducing gas to the mass of the catalyst is (3-20):1, where the unit of flow rate is mL/min and the unit of mass is g. Step 2. mixing o-fluoronitrobenzene steam and hydrogen preheated to 150°C ~ 260°C to uniformly obtain a mixed gas, and the mixed gas is introduced into the fixed bed reactor, and at the same time, the reducing gas diluted with nitrogen is stopped, Under the condition of reaction temperature of 120°C ~ 280°C, a catalytic hydrogenation reaction is carried out on the catalyst; step 3., the material after the catalytic hydrogenation reaction in step 2 is sent to the condenser for condensation, the o-fluoroaniline vapor in the material is converted into a liquid state, and then the o-fluoroaniline converted into a liquid state is separated by an oil-water separator to obtain an oily o-fluoroaniline. |
| application of o-fluoroaniline | o-fluoroaniline is an important intermediate for the synthesis of fluorine-containing medicines and dyes. O-fluoroaniline can be used to synthesize heat-sensitive dye FH-102, which is a kind of heat-sensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, cardiac electroencephalogram recording paper, telephone fax paper and transparent thermal film for oil field. |
| o-fluoroaniline | o-fluoroaniline is a colorless to light yellow transparent liquid, toxic, insoluble in water, soluble in ethanol and ether, and can be used as An analytical reagent has a stimulating effect on the skin. Vapor or smoke has a stimulating effect on the eyes, mucous membranes and upper respiratory tract. When entering the human body, it can form cyanosis caused by methemoglobin. Its vapor and air can form an explosive mixture, which will cause combustion and explosion when exposed to open flames and high heat energy. It can react with oxidant. It is decomposed by high heat and releases toxic gases. In case of high heat, the internal pressure of the container increases, and there is a risk of cracking and explosion. |
| Use | Used as an intermediate in medicine, pesticides and dyes |
| spontaneous combustion temperature | 600°C |
Last Update：2024-04-09 02:00:05
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View History
348-54-9
MGC138156
7791-07-3
5-bromo indole
Apple calciuM
boron orthophosphate
ATLANTICHROME BROWN RH
Methyl 4-bromophenylacetate
2-{[(2-AMINOPHENYL)SULFONYL]AMINO}ACETAMIDE
丁二酰氯
MGC138156
7791-07-3
5-bromo indole
Apple calciuM
boron orthophosphate
ATLANTICHROME BROWN RH
Methyl 4-bromophenylacetate
2-{[(2-AMINOPHENYL)SULFONYL]AMINO}ACETAMIDE
丁二酰氯
Raw Materials for 348-54-9