3338-34-9
(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate
CAS: 3338-34-9
Molecular Formula: C23H31N3O8
3338-34-9 - Names and Identifiers
3338-34-9 - Physico-chemical Properties
| Molecular Formula | C23H31N3O8 |
| Molar Mass | 477.51 |
| Storage Condition | -15°C |
3338-34-9 - Risk and Safety
| HS Code | 29251900 |
3338-34-9 - Introduction
(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropyl-2-yl) oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate ((2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropyl-2-yl) oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate) is an organic compound with the following properties:
1. Appearance: (2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate is a white or off-white solid.
2. molecular formula: C25H38N4O8
3. Molecular weight: 526.6g/mol
4. melting point: about 80-85 ℃
5. Solubility:(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate is soluble in common organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropyl-2-yl) oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate is mainly used for peptide synthesis reactions in solid phase synthesis. It is used as an active coupling reagent in peptide synthesis to link amino acid units with protecting groups. The compound has good reactivity and selectivity, which can promote the coupling reaction of amino acids with the end of other peptide chains.
The method for preparing (2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate usually includes the following steps:
1. First, Lys(Boc)-OH was dissolved in dimethylformamide (DMF) under anhydrous conditions.
2. Add O-(Boc) 6-amino hexanoic acid hydrochloride to the solution, and stir the reaction at room temperature to generate N-(Boc) 6-amino acid.
3. The obtained N-(Boc) 6-amino acid is reacted with N-hydroxysuccinimide (NHS) and dicyclohexylcarbodiimide (DCC) to generate (2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate.
Regarding safety information,(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropyl-2-yl) oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate may be irritating and dangerous. When handling and using, please follow appropriate safety measures and wear appropriate personal protective equipment.
1. Appearance: (2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate is a white or off-white solid.
2. molecular formula: C25H38N4O8
3. Molecular weight: 526.6g/mol
4. melting point: about 80-85 ℃
5. Solubility:(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate is soluble in common organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropyl-2-yl) oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate is mainly used for peptide synthesis reactions in solid phase synthesis. It is used as an active coupling reagent in peptide synthesis to link amino acid units with protecting groups. The compound has good reactivity and selectivity, which can promote the coupling reaction of amino acids with the end of other peptide chains.
The method for preparing (2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate usually includes the following steps:
1. First, Lys(Boc)-OH was dissolved in dimethylformamide (DMF) under anhydrous conditions.
2. Add O-(Boc) 6-amino hexanoic acid hydrochloride to the solution, and stir the reaction at room temperature to generate N-(Boc) 6-amino acid.
3. The obtained N-(Boc) 6-amino acid is reacted with N-hydroxysuccinimide (NHS) and dicyclohexylcarbodiimide (DCC) to generate (2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate.
Regarding safety information,(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropyl-2-yl) oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate may be irritating and dangerous. When handling and using, please follow appropriate safety measures and wear appropriate personal protective equipment.
Last Update：2024-04-10 22:29:15
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CAS: 3338-34-9
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