325958-97-2
2-bromo-5-trimethylsilylpyridine;2-bromo-5-(trimethylsilyl)pyridine
CAS: 325958-97-2
Molecular Formula: C8H12BrNSi
325958-97-2 - Names and Identifiers
| Name | 2-bromo-5-trimethylsilylpyridine 2-bromo-5-(trimethylsilyl)pyridine |
| Synonyms | 2-bromo-5-trimethylsilylpyridine 2-bromo-5-(trimethylsilyl)pyridine Pyridine, 2-bromo-5-(trimethylsilyl)- |
| CAS | 325958-97-2 |
325958-97-2 - Physico-chemical Properties
| Molecular Formula | C8H12BrNSi |
| Molar Mass | 230.18 |
| Density | 1.27 |
| Boling Point | 249℃ |
| Flash Point | 105℃ |
| pKa | 1.27±0.10(Predicted) |
325958-97-2 - Introduction
2-bromo-5-(trimethylsilyl)pyridine is an organic compound with the chemical formula C9H12BrNSi and a molecular weight of 223.26g/mol. The following is a description of some properties, uses, preparation and safety information about the compound:
Nature:
-Appearance: Colorless or light yellow liquid
-Melting point:-10 ° C
-Boiling point: 107-110 ° C (0.2 mmHg)
-Density: 1.157 g/mL
-Solubility: Soluble in organic solvents such as ether, dimethyl sulfoxide and methanol
Use:
2-bromo-5-(trimethylsilyl)pyridine is a commonly used organic synthesis reagent and has certain application value. It is often used as an intermediate in organic synthesis and can participate in a variety of chemical reactions, such as substitution reactions, coupling reactions and so on. The compounds can be used as synthetic organometallic compounds, pharmaceutically active molecules and ligands, etc.
Method:
2-bromo-5-(trimethylsilyl)pyridine can be prepared by the following steps:
1. Pyridine and dimethylsilylaluminum chloride are mixed and reacted at room temperature to generate dimethylsilylpyridine.
2. Adding sodium bromide to dimethyl silyl pyridine in ethanol to generate 2-bromo -5-dimethyl silyl pyridine.
3. Bromo -5-dimethylsilyl pyridine and trimethylsilyl ethanone reagent react to produce the final product; 2-bromo-5-(trimethylsilyl)pyridine.
Safety Information:
About: 2-bromo-5-(trimethylsilyl) has limited safety information, and appropriate laboratory safety measures need to be taken when using it. This compound may be irritating to the eyes and skin and should be rinsed with plenty of water immediately after contact. Wear appropriate protective glasses, gloves and protective clothing when using. It shall not be stored or handled with inflammable substances such as oxidizers to prevent fire accidents. At the same time, it should also be operated in a well-ventilated place to avoid inhaling its vapor.
Nature:
-Appearance: Colorless or light yellow liquid
-Melting point:-10 ° C
-Boiling point: 107-110 ° C (0.2 mmHg)
-Density: 1.157 g/mL
-Solubility: Soluble in organic solvents such as ether, dimethyl sulfoxide and methanol
Use:
2-bromo-5-(trimethylsilyl)pyridine is a commonly used organic synthesis reagent and has certain application value. It is often used as an intermediate in organic synthesis and can participate in a variety of chemical reactions, such as substitution reactions, coupling reactions and so on. The compounds can be used as synthetic organometallic compounds, pharmaceutically active molecules and ligands, etc.
Method:
2-bromo-5-(trimethylsilyl)pyridine can be prepared by the following steps:
1. Pyridine and dimethylsilylaluminum chloride are mixed and reacted at room temperature to generate dimethylsilylpyridine.
2. Adding sodium bromide to dimethyl silyl pyridine in ethanol to generate 2-bromo -5-dimethyl silyl pyridine.
3. Bromo -5-dimethylsilyl pyridine and trimethylsilyl ethanone reagent react to produce the final product; 2-bromo-5-(trimethylsilyl)pyridine.
Safety Information:
About: 2-bromo-5-(trimethylsilyl) has limited safety information, and appropriate laboratory safety measures need to be taken when using it. This compound may be irritating to the eyes and skin and should be rinsed with plenty of water immediately after contact. Wear appropriate protective glasses, gloves and protective clothing when using. It shall not be stored or handled with inflammable substances such as oxidizers to prevent fire accidents. At the same time, it should also be operated in a well-ventilated place to avoid inhaling its vapor.
Last Update：2024-04-09 21:54:55
