3-氯-4-氟硝基苯
3-CHLORO-4-FLUORONITROBENZENE
CAS: 350-30-1
Molecular Formula: C6H3ClFNO2
3-氯-4-氟硝基苯 - Names and Identifiers
3-氯-4-氟硝基苯 - Physico-chemical Properties
| Molecular Formula | C6H3ClFNO2 |
| Molar Mass | 175.54 |
| Density | 1.61 |
| Melting Point | 40-42°C(lit.) |
| Boling Point | 227-232°C |
| Flash Point | >230°F |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.0893mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow to Green |
| BRN | 1944997 |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Sensitive to air |
| Refractive Index | 1.554 |
| MDL | MFCD00007206 |
| Physical and Chemical Properties | White crystals. The melting point is 44-47 °c, the boiling point is 227-237 °c, and the flash point is> 110 °c. |
3-氯-4-氟硝基苯 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | CZ0720000 |
| HS Code | 29049090 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
3-氯-4-氟硝基苯 - Nature
Open Data Verified Data
white crystals. Melting point 44~47 ℃, boiling point 227~237 ℃, flash point> 110 ℃. This product is irritating.
Last Update：2025-06-10 22:55:16
3-氯-4-氟硝基苯 - Application
Open Data Verified Data
This product can be used for the preparation of 3 chloro -4-fluoroaniline, is the basic raw material for the synthesis of drugs such as quinonic acid.
Last Update：2025-08-19 16:24:40
3-氯-4-氟硝基苯 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | 2-chloro-1-fluoro-4-nitrobenzene, also known as 3-chloro-4-fluoronitrobenzene, is an intermediate of norfloxacin and can also be used to produce 3-chloro-4-fluoroaniline. it is the basic raw material for the synthesis of quinnoic acid and other drugs , and can also be used in pesticide production and other aspects. 3-chloro-4-fluoronitrobenzene can be used to prepare 3-chloro-4-fluoroaniline hydrochloride. 3-chloro-4-fluoroaniline is a very important starting material in the synthesis of anticancer drug gefitinib, and it is also an important intermediate in the synthesis of antibacterial drug norfloxacin. In addition, 3-chloro-4-fluoroaniline is also an important intermediate for the synthesis of fluorine-containing pesticide herbicides, plant growth regulators, fungicides, etc. |
| application | 3-chloro-4-fluoronitrobenzene is an important pharmaceutical and pesticide intermediate. if 3-chloro-4-fluoroaniline is reduced, norfloxacin can be prepared; if 2, 4-dichlorofluorobenzene is prepared by chlorination and denitration, ciprofloxacin can be prepared by further synthesis. |
| use | intermediate of norfloxacin. It can also be used to make 3-chloro-4-fluoroaniline, which is the basic raw material for the synthesis of quinnoic acid and other drugs. It is an important pharmaceutical and pesticide intermediate. If 3-chloro-4-fluoroaniline is obtained by reduction, norfloxacin can be obtained, and 2,4-dichlorofluorobenzene can be obtained by chlorination and denitration. Ciprofloxacin can be prepared by further synthesis. |
| production method | nitration with fluorobenzene with mixed acid to generate p-fluoronitrobenzene, and then chlorination with chlorine to prepare the product. |
| category | toxic substances |
| flammability hazard characteristics | flammability; fire scene decomposition of toxic nitrogen oxides; fluoride and chloride smoke |
| storage and transportation characteristics | warehouse low temperature, ventilation, drying |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 02:00:08
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View History
3-氯-4-氟硝基苯
N-BOC-RS-环丙基丙氨酸
9H-Fluorene-2-carboxaldehyde
3-氯哒嗪-4-甲酸甲酯
2-溴-5-环丙基吡啶
三甲硅烷基三氟乙酸酯
HO-PEG2-t-Butyl ester
N-BOC-RS-环丙基丙氨酸
9H-Fluorene-2-carboxaldehyde
3-氯哒嗪-4-甲酸甲酯
2-溴-5-环丙基吡啶
三甲硅烷基三氟乙酸酯
HO-PEG2-t-Butyl ester