3-氨基哌啶-1-羧酸苄酯
1-N-Cbz-3-aminopiperidine
CAS: 711002-74-3
Molecular Formula: C13H18N2O2
3-氨基哌啶-1-羧酸苄酯 - Names and Identifiers
| Name | 1-N-Cbz-3-aminopiperidine |
| Synonyms | 1-Cbz-3-amino piperidine 1-N-Cbz-3-aminopiperidine 1-N-CBZ-3-AMINOPIPERIDINE 3-AMINO-1-N-CBZ-PIPERIDINE DL-3-AMINO-1-N-CBZ-PIPERIDINE 3-AMINOPIPERIDINE, N1-CBZ PROTECTED 3-Amino-1-benzyloxycarbonylpiperidine Benzyl 3-aminopiperidine-1-carboxylate 3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 3-Amino-piperidine-1-carboxylic acid benzyl ester |
| CAS | 711002-74-3 |
| InChI | InChI=1/C13H18N2O2/c14-12-7-4-8-15(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,14H2 |
3-氨基哌啶-1-羧酸苄酯 - Physico-chemical Properties
| Molecular Formula | C13H18N2O2 |
| Molar Mass | 234.29 |
| Density | 1.151±0.06 g/cm3(Predicted) |
| Melting Point | 168-170°C |
| Boling Point | 367.2±42.0 °C(Predicted) |
| Flash Point | 175.9°C |
| Vapor Presure | 1.38E-05mmHg at 25°C |
| pKa | 10.33±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.558 |
3-氨基哌啶-1-羧酸苄酯 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN1760 |
| HS Code | 29333990 |
3-氨基哌啶-1-羧酸苄酯 - Introduction
1-N-Cbz-3-aminopiperidine(1-N-Cbz-3-aminopiperidine) is an organic compound, which is substituted with one amino and one benzyloxycarbonyl (Cbz) group on the piperidine nucleus. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless crystalline solid
-Molecular formula: C14H18N2O
-Molecular weight: 230.31g/mol
-melting point: 68-71 ℃
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
1-N-Cbz-3-aminopiperidine is commonly used as an intermediate in organic synthesis and has the following applications:
-For the preparation of drugs and biologically active substances
-for the synthesis of biologically active compounds
-Can be used as a synthetic raw material for antiarrhythmic drugs
Preparation Method:
The preparation method of 1-N-Cbz-3-aminopiperidine generally involves the following steps:
1. First, piperidine is reacted with an amination reagent (such as acetone oxime or isocyanate) to generate an amino derivative of piperidine.
2. The amino derivative of piperidine is then reacted with benzyl bicarbonate (CbzH) to produce 1-N-Cbz-3-aminopiperidine.
Safety Information:
The relevant safety information of 1-N-Cbz-3-aminopiperidine is limited, so care should be taken when handling and operating.
-May cause irritation to eyes, skin and respiratory tract, so contact should be avoided.
-Wear appropriate protective equipment, such as laboratory gloves and goggles, to ensure good indoor ventilation.
-Should be stored in a dry and cool place, and away from combustibles and oxidants.
Nature:
-Appearance: Colorless crystalline solid
-Molecular formula: C14H18N2O
-Molecular weight: 230.31g/mol
-melting point: 68-71 ℃
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
1-N-Cbz-3-aminopiperidine is commonly used as an intermediate in organic synthesis and has the following applications:
-For the preparation of drugs and biologically active substances
-for the synthesis of biologically active compounds
-Can be used as a synthetic raw material for antiarrhythmic drugs
Preparation Method:
The preparation method of 1-N-Cbz-3-aminopiperidine generally involves the following steps:
1. First, piperidine is reacted with an amination reagent (such as acetone oxime or isocyanate) to generate an amino derivative of piperidine.
2. The amino derivative of piperidine is then reacted with benzyl bicarbonate (CbzH) to produce 1-N-Cbz-3-aminopiperidine.
Safety Information:
The relevant safety information of 1-N-Cbz-3-aminopiperidine is limited, so care should be taken when handling and operating.
-May cause irritation to eyes, skin and respiratory tract, so contact should be avoided.
-Wear appropriate protective equipment, such as laboratory gloves and goggles, to ensure good indoor ventilation.
-Should be stored in a dry and cool place, and away from combustibles and oxidants.
Last Update：2024-04-09 20:49:11
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Mobile: +86-18621343501
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View History
3-氨基哌啶-1-羧酸苄酯
[(Trimethylstannyl)ethynyl]trimethylstannane
5-甲基-4-1,3-恶唑羧酸
4-Trifluoromethoxybenzenesulphonyl amine
[(Trimethylstannyl)ethynyl]trimethylstannane
5-甲基-4-1,3-恶唑羧酸
4-Trifluoromethoxybenzenesulphonyl amine