2973-27-5
Quinoline-4-carbonitrile
CAS: 2973-27-5
Molecular Formula: C10H6N2
2973-27-5 - Names and Identifiers
| Name | Quinoline-4-carbonitrile |
| Synonyms | 4-CYANOQUINOLINE cinchoninonitrile 4-Quinolinecarbonitrile Quinoline-4-carbonitrile QUINOLINE-4-CARBONITRILE |
| CAS | 2973-27-5 |
| InChI | InChI=1/C10H6N2/c11-7-8-5-6-12-10-4-2-1-3-9(8)10/h1-6H |
2973-27-5 - Physico-chemical Properties
| Molecular Formula | C10H6N2 |
| Molar Mass | 154.17 |
| Density | 1.1975 (rough estimate) |
| Melting Point | 103.5°C |
| Boling Point | 267.53°C (rough estimate) |
| Flash Point | 95.2°C |
| Vapor Presure | 0.0325mmHg at 25°C |
| Appearance | White to off-white microcrystalline solid |
| pKa | 1.55±0.13(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4820 (estimate) |
2973-27-5 - Introduction
Quinoline-4-carbonitrile(Quinoline-4-carbonitrile) is an organic compound with the chemical formula C10H6N2. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: Quinoline-4-carbonitrile is a colorless or yellowish crystalline or powdery substance.
2. Melting Point: about 141-142 ° C.
3. Solubility: It is soluble in some organic solvents, such as alcohols, ethers and ketones.
Use:
Quinoline-4-carbonitrile have certain uses in the field of pharmaceutical and pesticide manufacturing. It can be used as an intermediate in the synthesis of some drugs and pesticides.
Method:
The preparation method of the Quinoline-4-carbonitrile can be completed by the following steps:
1. P-Thiobenzamide (p-Thiobenzanilide) reacts with potassium cyanide (KCN) in the presence of sodium chloride (NaCl) to give benzimidazole (Phenylimidazole).
2. The benzimidazole and tribromomethane (CBr4) are subjected to nucleophilic substitution reaction to generate 4-carbonitrile quinoline.
3. Finally, 4-carbonitrile quinoline is reacted with acid to obtain Quinoline-4-carbonitrile.
Safety Information:
1. Quinoline-4-carbonitrile irritant, contact with skin and eyes may cause irritation and inflammation. Wear protective gloves and goggles when using.
2. Avoid inhaling dust or gas during operation, and operate in a well-ventilated place.
3. Storage should be sealed and stored in a dry, cool place, away from fire and oxidant.
Nature:
1. Appearance: Quinoline-4-carbonitrile is a colorless or yellowish crystalline or powdery substance.
2. Melting Point: about 141-142 ° C.
3. Solubility: It is soluble in some organic solvents, such as alcohols, ethers and ketones.
Use:
Quinoline-4-carbonitrile have certain uses in the field of pharmaceutical and pesticide manufacturing. It can be used as an intermediate in the synthesis of some drugs and pesticides.
Method:
The preparation method of the Quinoline-4-carbonitrile can be completed by the following steps:
1. P-Thiobenzamide (p-Thiobenzanilide) reacts with potassium cyanide (KCN) in the presence of sodium chloride (NaCl) to give benzimidazole (Phenylimidazole).
2. The benzimidazole and tribromomethane (CBr4) are subjected to nucleophilic substitution reaction to generate 4-carbonitrile quinoline.
3. Finally, 4-carbonitrile quinoline is reacted with acid to obtain Quinoline-4-carbonitrile.
Safety Information:
1. Quinoline-4-carbonitrile irritant, contact with skin and eyes may cause irritation and inflammation. Wear protective gloves and goggles when using.
2. Avoid inhaling dust or gas during operation, and operate in a well-ventilated place.
3. Storage should be sealed and stored in a dry, cool place, away from fire and oxidant.
Last Update：2024-04-09 02:00:45
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View History
2973-27-5
35193-18-1
212844-54-7
L-高半胱氨酸
Aluminon(C.1.No.43810)
1795-31-9
959908-09-9
642-38-6
36019-37-1
431579-34-9
35193-18-1
212844-54-7
L-高半胱氨酸
Aluminon(C.1.No.43810)
1795-31-9
959908-09-9
642-38-6
36019-37-1
431579-34-9