28697-09-8

28697-09-8 - Names and Identifiers

Name	(D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID
Synonyms	(D)-N-CBZ-PIPECOLIC ACID (R)-1-CBZ-PIPERIDINE-2-CARBOXYLIC ACID (D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID N-BENZYLOXYCARBONYL-(R)-(+)-PIPECOLINIC ACID (R)-(+)-N-BENZYLOXYCARBONYL-PIPECOLINIC ACID (R)-N-CARBOBENZYLOXY-2-PIPERIDINECARBOXYLIC ACID 1-[(benzyloxy)carbonyl]piperidine-2-carboxylic acid (R)-1-(BENZYLOXYCARBONYL)PIPERIDINE-2-CARBOXYLIC ACID (R)-(+)-1-(CARBOBENZYLOXY)-2-PIPERIDINECARBOXYLIC ACID (2R)-1-[(benzyloxy)carbonyl]piperidine-2-carboxylic acid 1,2-piperidinedicarboxylic acid, 1-(phenylmethyl) ester, (2R)-
CAS	28697-09-8
InChI	InChI=1/C14H17NO4/c16-13(17)12-8-4-5-9-15(12)14(18)19-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10H2,(H,16,17)

28697-09-8 - Physico-chemical Properties

Molecular Formula	C14H17NO4
Molar Mass	263.29
Density	1.265g/cm³
Melting Point	111-115°C(lit.)
Boling Point	443.9°C at 760 mmHg
Flash Point	222.3°C
Solubility	Dichloromethane, Ethyl Acetate, Methanol
Vapor Presure	1.16E-08mmHg at 25°C
Appearance	Oil
Color	Colourless
Storage Condition	00C
Refractive Index	1.568

28697-09-8 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R38 - Irritating to the skin R37 - Irritating to the respiratory system R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

28697-09-8 - Introduction

(D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID is an organic compound with the chemical formula C20H21NO4 which is a (N-Benzyloxycarbonyl) derivative of (D)-N-piperidinylcarboxylic ACID.

Its nature:
-Appearance: White crystal or crystalline powder;
-Melting point: about 130-132 degrees Celsius;
-Solubility: Soluble in ethanol, chloroform, dichloromethane and other organic solvents, almost insoluble in water.

Its purpose:
(D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID is widely used in the field of organic synthesis. It is often used as an intermediate in the synthesis of other organic compounds, especially for the production of drugs and the synthesis of drug precursors.

Its preparation method:
The preparation of (D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID usually includes the following main steps:
1. (D)-N-piperidinyl carboxylic ACID reacts with organic carbonic anhydride (N-benzyloxy) to produce (D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID carbonate;
2. The (D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID carbonate is reacted with sodium hydroxide to be hydrolyzed into (D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID.

Safety Information:
(D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID has not been reported to cause serious harm to human health. However, any chemical should be used in an appropriate laboratory environment, following proper safe practices. The inhalation of dust should be avoided, skin contact and eye contact should be avoided, and appropriate protective equipment such as lab gloves and goggles should be used during the operation. If necessary, use chemical ventilation to ensure air circulation. When storing and handling the compound, care should be taken to avoid contact with strong oxidants and strong acids to prevent unsafe chemical reactions.

Last Update：2024-04-09 20:45:29