28320-73-2
Boc-Gly-Gly-Gly-OH
CAS: 28320-73-2
Molecular Formula: C11H19N3O6
28320-73-2 - Names and Identifiers
28320-73-2 - Physico-chemical Properties
| Molecular Formula | C11H19N3O6 |
| Molar Mass | 289.29 |
| Density | 1.263 |
| Melting Point | 205 °C |
| Boling Point | 641.8±50.0 °C(Predicted) |
| pKa | 3.33±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
28320-73-2 - Introduction
Tert-Butoxycarbonylglycyl glycylglycine (Boc-Gly-Gly-Gly-OH) is an organic compound with the following properties:
Nature:
-Appearance: usually white crystal or crystalline powder
-Molecular formula: C17H30N4O7
-Molecular weight: 402.44g/mol
-Melting point: about 130-132 ° C
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF), dichloromethane, chloroform, etc., insoluble in water.
Use:
Boc-Gly-Gly-Gly-OH are commonly used in organic synthesis, mainly as protecting groups or groups. It can be used as a protective group of amino acids to prevent non-specific reactions, and is commonly used in solid phase synthesis, peptide synthesis and drug synthesis.
Method:
A common method for preparing Boc-Gly-Gly-Gly-OH is to introduce a tert-butoxycarbonyl protecting group on the carboxyl group of glycine. Specific steps include:
1. Glycine is reacted with a mixture of sodium nitrite and sulfuric acid to obtain tert-butoxycarbonyl glycinate.
2. The Ester protecting group is removed by a hydrolysis reaction to obtain Boc-glycine.
3. Repeat the above steps twice to introduce the carboxyl group of glycine into two tert-butoxycarbonyl protecting groups respectively to obtain Boc-Gly-Gly-Gly-OH.
Safety Information:
The use of Boc-Gly-Gly-Gly-OH should pay attention to the following safety matters:
-Avoid contact with skin and eyes, as it may irritate the skin and eyes.
-Wear appropriate protective gloves, goggles and protective clothing during operation.
-Operate in a well-ventilated place to avoid inhaling its dust or vapor.
-should be stored away from fire, heat and oxidant, keep the container sealed, stored in a cool, dry place.
Nature:
-Appearance: usually white crystal or crystalline powder
-Molecular formula: C17H30N4O7
-Molecular weight: 402.44g/mol
-Melting point: about 130-132 ° C
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF), dichloromethane, chloroform, etc., insoluble in water.
Use:
Boc-Gly-Gly-Gly-OH are commonly used in organic synthesis, mainly as protecting groups or groups. It can be used as a protective group of amino acids to prevent non-specific reactions, and is commonly used in solid phase synthesis, peptide synthesis and drug synthesis.
Method:
A common method for preparing Boc-Gly-Gly-Gly-OH is to introduce a tert-butoxycarbonyl protecting group on the carboxyl group of glycine. Specific steps include:
1. Glycine is reacted with a mixture of sodium nitrite and sulfuric acid to obtain tert-butoxycarbonyl glycinate.
2. The Ester protecting group is removed by a hydrolysis reaction to obtain Boc-glycine.
3. Repeat the above steps twice to introduce the carboxyl group of glycine into two tert-butoxycarbonyl protecting groups respectively to obtain Boc-Gly-Gly-Gly-OH.
Safety Information:
The use of Boc-Gly-Gly-Gly-OH should pay attention to the following safety matters:
-Avoid contact with skin and eyes, as it may irritate the skin and eyes.
-Wear appropriate protective gloves, goggles and protective clothing during operation.
-Operate in a well-ventilated place to avoid inhaling its dust or vapor.
-should be stored away from fire, heat and oxidant, keep the container sealed, stored in a cool, dry place.
Last Update：2024-04-09 02:00:44
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