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269055-15-4

Etravirine

CAS: 269055-15-4;394729-17-0

Molecular Formula: C20H15BrN6O

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269055-15-4 - Names and Identifiers

Name Etravirine
Synonyms TMC125
TMC 125
TMC-125
R 165335
Intelence
Etravirine
R165335-TMC125
UNII-0C50HW4FO1
Unii-0C50hw4fo1
Etravirine [INN]
IntelenceBenzonitrile
4-[[6-AMino-5-broMo-2-[(4-cyanophenyl)aMino]-4-pyriMidinyl]oxy]-3,5-diMethyl -
6-amino-5-bromo-4-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyanophenylamino)pyrimidine
4-(6-Amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile
4-[6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl]oxy-3,5-dimethyl-benzonitrile
4-({6-amino-5-bromo-2-[(4-cyanophényl)amino]pyrimidin-4-yl}oxy)-3,5-diméthylbenzonitrile
4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile
4-({6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile
4-[[6-Amino-5-Bromo-2-[(4-Cyanophenyl)Amino]-4-Pyrimidinyl]Oxy]-3,5–Dimethylbenzonitrile
4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile
4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile
4-({6-Amino-5-brom-2-[(4-cyanphenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzolcarbonitril
4-(6-amino-5-bromo-2-(4-cyanobenzyl)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, Etravirine
benzonitrile, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-
Benzonitrile, 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-
CAS 269055-15-4
394729-17-0
EINECS 682-331-6
InChI InChI=1/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)

269055-15-4 - Physico-chemical Properties

Molecular FormulaC20H15BrN6O
Density1.439 g/cm3
Melting Point.265°C (dec.)
Boling Point637.4±65.0 °C(Predicted)
Flash Point339.3°C
Solubility DMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Vapor Presure3.82E-16mmHg at 25°C
AppearanceWhite to off-white solid
ColorWhite to Off-White
pKa1.23±0.10(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,Store in freezer, under -20°C
SensitiveSensitive to heat and light
Refractive Index1.702
In vitro studyEtravirine (TMC125), is high active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 μm. TMC125 also inhibit a series of HIV-1 group M subtypes and circular combined forms and a group O virus.
Etravirine (TMC125) was highly effective against wild-type HIV-1, with an EC50 of 1.4 nM to 4.8 nM, and showed some activity against HIV-2, with an EC50 of 3.5 μm. TMC125 also inhibits a series of HIV-1 M-type subunits and circulating recombinant forms as well as O-type Virus.
In vivo studyEtravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, included with virus resistant to NNRTIs and protein inhibitors (PIs), TMC125 is active against HIV resistant to current available NNRTIs, with a similar tolerance profile to that of the control group.
Etravirine has a high genetic barrier to resistance development. In the Phase IIb trial, TMC125 was active against existing NNRTIs-resistant HIV in multiple-treated patients, including those infected with NNRTIs-resistant and protease inhibitor-resistant (PIs) Virus, similar tolerability to the control group.
269055-15-4
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Shanghai Macklin Biochemical Co., Ltd
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5-dimethylbenzonitrile Visit Supplier Webpage Request for quotation
CAS: 269055-15-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Etravirine Request for quotation
CAS: 269055-15-4/394729-17-0
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Nantong Reform Petro-Chemical CO., LTD.
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Email: r@reformchem.com­
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Shanghai Amole Biotechnology Co., Ltd.
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Email: 3623107365@qq.com
Mobile: 18916960931
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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Product Name: 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5-dimethylbenzonitrile Visit Supplier Webpage Request for quotation
CAS: 269055-15-4
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MedChemExpress (MCE)
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
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CAS: 269055-15-4
Tel: 18301782025
Email: 3008007409@qq.com
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View History
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