2546-56-7
4-Chloro-3-fluoropyridine
CAS: 2546-56-7
Molecular Formula: C5H3ClFN
2546-56-7 - Names and Identifiers
| Name | 4-Chloro-3-fluoropyridine |
| Synonyms | 4-Chlor-3-fluorpyridin 4-CHLORO-3-FLUOROPYRIDINE 4-Chloro-3-fluoropyridine 3-FLUORO-4-CHLORO PYRIDINE Chlorofluoropyridine 43--- Pyridine, 4-chloro-3-fluoro- 2-Methyl-4-ChloropyridineHydrochloride 4-CHLORO-3-FLUOROPYRIDINE 4-CHLORO-3-FLUOROPYRIDINE |
| CAS | 2546-56-7 |
| EINECS | 629-495-7 |
| InChI | InChI=1/C5H3ClFN/c6-4-1-2-8-3-5(4)7/h1-3H |
2546-56-7 - Physico-chemical Properties
| Molecular Formula | C5H3ClFN |
| Molar Mass | 131.54 |
| Density | 1.333 g/mL at 25 °C (lit.) |
| Melting Point | -24°C(lit.) |
| Boling Point | 139°C(lit.) |
| Flash Point | 82.4°F |
| Vapor Presure | 8.19mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow to Light orange |
| BRN | 1422747 |
| pKa | 1.93±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5010 to 1.5050 |
2546-56-7 - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| Hazard Note | Flammable/Irritant |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
2546-56-7 - Introduction
4-Chloro-3-fluoropyridine is an organic compound with the chemical formula C5H3ClFN. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4-Chloro-3-fluoropyridine is a colorless to pale yellow liquid.
-Melting point: About -10 ℃ to -8 ℃
-Boiling point: about 130 ℃ to 135 ℃
-Density: about 1.36g/cm³
-Stability: The compound is stable at room temperature and will decompose slightly when exposed to light.
Use:
- 4-Chloro-3-fluoropyridine is commonly used in organic synthesis as an important reagent and intermediate.
-It can be used for the synthesis of pyridine compounds and the introduction of functional compounds.
- 4-Chloro-3-fluoropyridine can also be used as a raw material for pharmaceuticals, pesticides and other organic compounds.
Method:
The preparation of 4-Chloro-3-fluoropyridine is usually accomplished by chlorinating pyridine followed by fluorination.
-First, 4-chloropyridine is reacted with ferric chloride to generate chloropyridine.
-Then, react pyridine chloride with fluoride, such as potassium fluoride or silver fluoride, to obtain 4-Chloro-3-fluoropyridine.
-The reaction usually requires the use of solvents and catalysts, and appropriate control conditions.
Safety Information:
- 4-Chloro-3-fluoropyridine may be irritating to the skin and eyes, so you need to wear appropriate personal protective equipment, such as gloves and goggles, during operation.
-When in contact with skin or eyes, rinse immediately with plenty of water.
- 4-Chloro-3-fluoropyridine should be kept away from fire and oxidizing agents and stored in a dry, cool place.
-When using or operating, please refer to the relevant safety technical instructions and follow the appropriate laboratory practices.
Nature:
-Appearance: 4-Chloro-3-fluoropyridine is a colorless to pale yellow liquid.
-Melting point: About -10 ℃ to -8 ℃
-Boiling point: about 130 ℃ to 135 ℃
-Density: about 1.36g/cm³
-Stability: The compound is stable at room temperature and will decompose slightly when exposed to light.
Use:
- 4-Chloro-3-fluoropyridine is commonly used in organic synthesis as an important reagent and intermediate.
-It can be used for the synthesis of pyridine compounds and the introduction of functional compounds.
- 4-Chloro-3-fluoropyridine can also be used as a raw material for pharmaceuticals, pesticides and other organic compounds.
Method:
The preparation of 4-Chloro-3-fluoropyridine is usually accomplished by chlorinating pyridine followed by fluorination.
-First, 4-chloropyridine is reacted with ferric chloride to generate chloropyridine.
-Then, react pyridine chloride with fluoride, such as potassium fluoride or silver fluoride, to obtain 4-Chloro-3-fluoropyridine.
-The reaction usually requires the use of solvents and catalysts, and appropriate control conditions.
Safety Information:
- 4-Chloro-3-fluoropyridine may be irritating to the skin and eyes, so you need to wear appropriate personal protective equipment, such as gloves and goggles, during operation.
-When in contact with skin or eyes, rinse immediately with plenty of water.
- 4-Chloro-3-fluoropyridine should be kept away from fire and oxidizing agents and stored in a dry, cool place.
-When using or operating, please refer to the relevant safety technical instructions and follow the appropriate laboratory practices.
Last Update：2024-04-09 21:01:54
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