24211-30-1
Farrerol
CAS: 24211-30-1
Molecular Formula: C17H16O5
24211-30-1 - Names and Identifiers
| Name | Farrerol |
| Synonyms | FARREROL Farrerol CYRTPOTERINETIN CYRTOPTERINETIN 5,7-Dihydroxy-2-(4-hydroxyphenyl) 5,7,4'-TRIHYDROXY-6,8-DIMETHYLFLAVANONE 6,8-Dimethyl-4',5,7-Trihydroxyflavanone 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE 6,8-DIMETHYL-5,7,4'-TRIHYDROXYFLAVANONE 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6,8-diMethylchroMan-4-one 5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one (S)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one |
| CAS | 24211-30-1 |
| EINECS | 246-080-2 |
| InChI | InChI=1/C17H16O5/c1-8-15(20)9(2)17-14(16(8)21)12(19)7-13(22-17)10-3-5-11(18)6-4-10/h3-6,13,18,20-21H,7H2,1-2H3/t13-/m0/s1 |
24211-30-1 - Physico-chemical Properties
| Molecular Formula | C17H16O5 |
| Molar Mass | 300.31 |
| Density | 1.39 |
| Melting Point | 212-220 °C |
| Boling Point | 583.0±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.1 in MeOH) -23 |
| Flash Point | 220℃ |
| Solubility | Soluble in hot methanol, DMSO and other solvents, insoluble in petroleum ether, chloroform. |
| Vapor Presure | 3.44E-14mmHg at 25°C |
| Appearance | Beige powder |
| Color | Pale Yellow |
| pKa | 8.22±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.662 |
| MDL | MFCD28347824 |
| Physical and Chemical Properties | From cuckoo. |
| In vitro study | Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Farrerol inhibits angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition. Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy. |
| In vivo study | Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways. |
24211-30-1 - Risk and Safety
| HS Code | 29329990 |
24211-30-1 - Reference Information
| expectorant | Rhododendron is an expectorant drug extracted from Manshanhong and other Rhododendron plants. It has been artificially synthesized and directly acts on the respiratory tract Mucosa, promotes cilia movement, enhances the function of trachea and bronchus to mechanically remove foreign bodies, can break the acidic glycoprotein fiber in sputum, reduce the salivary acid content, and reduce the sputum viscosity, sputum becomes thinner and easy to cough up, while gradually reducing the amount of sputum. The expectorant effect for patients with chronic bronchitis is definite, the curative effect is long-lasting and stable, so that the amount of sputum is significantly reduced, the viscosity is reduced, and the symptoms are reduced. Clinically, it is mainly used for phlegm viscosity caused by chronic bronchitis. The tablets are 50~100mg per tablet. Oral 1 day 3 times, 1 time 50~100mg. Use with caution in patients with liver history and liver insufficiency. |
| biological activity | Farrerol is an important active ingredient in azalea, with antioxidant and anti-inflammatory activities. |
| in vitro study | Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation. Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Farrerol inhibits angiogenesis through Akt/mTOR, erk and Jak2/Stat3 signal pathway. Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition. Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy. |
| in vivo study | Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways. |
| chemical properties | from cuckoo. |
| use | used for content determination/identification/pharmacological experiments, etc. |
Last Update：2024-04-09 20:52:54
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View History
24211-30-1
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61563-28-8
三氟乙酰氯氯
37859-42-0
Pulsatilla saponin D (SB365)
美西律杂质 6
1876707-94-6
莲心碱高氯酸盐
1-溴十四烷
Cyanomethyl bromide