23642-66-2

Name	Benfluorex, Hydrochloride
Synonyms	Balans JP 992 Mediaxal Mediator mediator Lipophoral Benfluorex HCl UNII-X7O165XZ00 BENFLUOREX HYDROCHLORIDE Benfluorex hydrochloride Benfluorex, Hydrochloride 2-(alpha-Methyl-3-(trifluoromethyl)phenylethylamino)ethyl benzoat 2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-ethanobenzoate(est 2-(-Methyl-3-(trifluoromethyl)phenethylamino)ethyl benzoate hydrochloride 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-ethanobenzoate(est 2-((alpha-Methyl-m-(trifluoromethyl)phenethyl)amino)ethanol benzoate (ester) 2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride 2-((1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL)AMINO)ETHYL BENZOATE HYDROCHLORIDE 2-((1-Methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl benzoate hydrochloride 2-[[1-METHYL-2-[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE (ESTER) HCL Ethanol, 2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-, benzoate (ester), HCl 2-[[1-METHYL-2[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE ESTER HYDROCHLORIDE Ethanol, 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-, benzoate (ester), hydrochloride
CAS	23642-66-2
EINECS	245-801-8
InChI	InChI=1/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H

Molecular Formula	C19H21ClF3NO2
Molar Mass	387.82
Melting Point	158-159?C
Boling Point	420.5°C at 760 mmHg
Flash Point	208.1°C
Solubility	Chlorform (Slightly), Methanol (Slightly), Water (Slightly)
Vapor Presure	2.81E-07mmHg at 25°C
Appearance	neat
Color	White
Storage Condition	Refrigerator
In vitro study	Benfluorex hydrochloride consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex hydrochloride increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex hydrochloride stimulates HNF4α expression. Benfluorex hydrochloride alters HNF4α protease sensitivity, while the inactive control compound does not. Benfluorex hydrochloride decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of 14 CO 2 into citric acid cycle is markedly increased by Benfluorex hydrochloride. Benfluorex hydrochloride inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM).

Hazard Symbols	Xi - Irritant
WGK Germany	2
RTECS	KL8275000
Hazard Note	Irritant
Toxicity	LD50 intraperitoneal in mouse: 108mg/kg

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