2339-78-8
1,2-dichloro-4-fluoro-5-nitrobenzene
CAS: 2339-78-8
Molecular Formula: C6H2Cl2FNO2
2339-78-8 - Names and Identifiers
| Name | 1,2-dichloro-4-fluoro-5-nitrobenzene |
| Synonyms | 4,5-Dichloro-2-fluoronitrobenzene 1,2-DICHLORO-4-FLUORO-5-NITROBENZENE 1,2-dichloro-4-fluoro-5-nitrobenzene 3,4-Dichloro-2-fluoro-1-nitrobenzene 4-amino-5-fluoro-1-pentofuranosylpyrimidin-2(1H)-one |
| CAS | 2339-78-8 |
| InChI | InChI=1/C9H12FN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17) |
2339-78-8 - Physico-chemical Properties
| Molecular Formula | C6H2Cl2FNO2 |
| Molar Mass | 209.99 |
| Density | 1.596 g/mL at 25 °C (lit.) |
| Melting Point | 17 °C (lit.) |
| Boling Point | 247 °C (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 1.34E-12mmHg at 25°C |
| Appearance | Low Melting Solid |
| Color | Pale yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.575(lit.) |
2339-78-8 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| Hazard Note | Irritant |
2339-78-8 - Reference Information
| Use | 1, 2-dichloro-4-fluoro-5-nitrobenzene is also called 2-fluoro-4, 5-dichloronitrobenzene As an important pharmaceutical and pesticide intermediate, it has a wide range of uses. For example, 1) dibenzocycloheptene derivatives can be synthesized, which can treat neurological disorders; 2) benzenesulfonamide and benzimidazole derivatives with antibacterial properties; 3) quinazoline derivatives can effectively inhibit the activity of protein tyrosine kinase and reduce the incidence of cancer and diabetes; 4) pyrimidine carboxylic acid Derivatives, they are a broad-spectrum and efficient herbicide. |
| preparation | acetylation and chlorination in one pot: add 22.2g of newly steamed p-fluoroaniline and 60 mL of glacial acetic acid to the reaction container, raise the temperature to 30 ℃, add 20.4g of acetic anhydride drop by drop under stirring. After acetic anhydride dripping, it is heated to 60~70 ℃, and the heat preservation reaction is over. Slightly cooling to 40 ℃, slowly introducing Cl2, maintaining the reaction temperature at 40~50 ℃, holding the reaction for 12 h, and the reaction is over. Pour the product into 500 mL of ice water, precipitate solid, filter, adjust the mother liquor to neutral with Na2CO3 and then filter to obtain crude product. The 60% ethanol aqueous solution was recrystallized to obtain 29.8g of white needle-like solid 2-chloro-4-fluoroacetanilide with a yield of 79.1%. |
Last Update：2024-04-10 22:29:15
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View History
2339-78-8
1856083-50-5
Magnesium carbonate [USAN]
甲基壬酸酯
4-nitro-o-creso
1307艳红6B
12220-90-5
五亚甲基二溴
34451-26-8
一水泛酸钙
1856083-50-5
Magnesium carbonate [USAN]
甲基壬酸酯
4-nitro-o-creso
1307艳红6B
12220-90-5
五亚甲基二溴
34451-26-8
一水泛酸钙