22348-32-9
(R)-Diphenylprolinol
CAS: 22348-32-9
Molecular Formula: C17H19NO
22348-32-9 - Names and Identifiers
22348-32-9 - Physico-chemical Properties
| Molecular Formula | C17H19NO |
| Molar Mass | 253.35 |
| Density | 1.0078 (rough estimate) |
| Melting Point | 77-80°C |
| Boling Point | 396.54°C (rough estimate) |
| Specific Rotation(α) | 59 º (589nm, c=3, MeOH 25 ºC) |
| Flash Point | 133.3°C |
| Vapor Presure | 1.67E-07mmHg at 25°C |
| Appearance | White powder |
| Color | white to off-white |
| BRN | 4353363 |
| pKa | 13.15±0.29(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 58 ° (C=2, MeOH) |
| MDL | MFCD00077754 |
| Physical and Chemical Properties | Melting point 77-81°C specific rotation 59 ° (589nm, c = 3, MeOH 25°C) |
| Use | It is used to prepare the corresponding oxazoborane, which can be used for the borane-mediated asymmetric reduction reaction of ketones. |
22348-32-9 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-34 |
| TSCA | No |
| HS Code | 29221990 |
22348-32-9 - Reference Information
| Use | (R)-( )-α, α-diphenyl-2-pyrrolidine methanol has been proven to have amphetamine-like effects and is used in recreational drugs. It is a new class of synthetic stimulants called piprado derivatives. It inhibits neurite growth in PC12 cells, which contributes to its neurotoxic effects. It is used as a reagent in the synthesis of the antidepressant (S)-duloxetine. It is used to prepare chiral Corey-Bakshi-Shibata catalysts for organic synthesis. It is used to prepare the corresponding oxazolobane, which can be used for the borane-mediated asymmetric reduction reaction of ketones. |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
Last Update：2024-04-09 21:54:55
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