2-PYRIDINECARBOXAMIDE
Pyridine-2-carboxamide
CAS: 1452-77-3
Molecular Formula: C6H6N2O
2-PYRIDINECARBOXAMIDE - Names and Identifiers
| Name | Pyridine-2-carboxamide |
| Synonyms | 2-Picolinamide 2-PICOLINAMIDE Picolinoylamide Isoniazid Impurity I Picolinic acid amide 2-PYRIDINECARBOXAMIDE Pyridine-2-carboxamide Pyridine-2-carboxylicamide alpha-Picolinic acid amide Nicotinamide EP Impurity C 2-chloro-1-trityl-1H-imidazole Pyridine-2-carboxamide,(2-Picolinamide) |
| CAS | 1452-77-3 |
| EINECS | 215-921-5 |
| InChI | InChI=1/C22H17ClN2/c23-21-24-16-17-25(21)22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-17H |
2-PYRIDINECARBOXAMIDE - Physico-chemical Properties
| Molecular Formula | C6H6N2O |
| Molar Mass | 122.12 |
| Density | 1.2236 (rough estimate) |
| Melting Point | 110°C (dec.)(lit.) |
| Boling Point | 143 °C / 20mmHg |
| Flash Point | 273.4°C |
| Solubility | Dissolve (35g/L) (25°C), |
| Vapor Presure | 2.95E-11mmHg at 25°C |
| Appearance | White-like powder |
| Color | White to Off-White |
| BRN | 109617 |
| pKa | pK1: 2.10(+1) (20°C) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5350 (estimate) |
| MDL | MFCD00023483 |
| In vivo study | In rats given a single injection (picolinamide, 4 mmol/kg),picolinamide inhibited the co-transport of Na /phosphate by renal brush border membrane vesicles. There was a small (1.5-fold) increase in renal cortical NAD content after picolinamide treatment. |
2-PYRIDINECARBOXAMIDE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29333990 |
2-PYRIDINECARBOXAMIDE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine) is a powerful PARP inhibitor in the nucleus of rat islet. |
| Target | Value |
| PARP | 95 μM |
Last Update：2024-04-09 02:00:07
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