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2-NITROFLUOROBENZENE

1-Fluoro-2-nitrobenzene

CAS: 1493-27-2

Molecular Formula: C6H4FNO2

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2-NITROFLUOROBENZENE - Names and Identifiers

Name 1-Fluoro-2-nitrobenzene
Synonyms Fluoronitrobenzene1
O-NITROFLUOROBENZENE
O-FLUORONITROBENZENE
2-flouromitrobrnzene
2-Fluoronitrobenzene
2-NITROFLUOROBENZENE
Olanzapine Impurity 2
Olanzapine Impurity 14
1-fluoro-2-nitro-benzen
1-Fluoro-2-nitrobenzene
Benzene, o-nitrofluoro-
1- fluorine-2- nitrobenzene
Adjacent fluoro nitrobenzene
(3-fluoro-4-methoxyphenyl)boronic acid
1-fluoro-2-nitro-benzene radical anion
CAS 1493-27-2
EINECS 216-088-0
InChI InChI=1/C7H8BFO3/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4,10-11H,1H3

2-NITROFLUOROBENZENE - Physico-chemical Properties

Molecular FormulaC6H4FNO2
Molar Mass141.1
Density1.338 g/mL at 25 °C (lit.)
Melting Point-9--6 °C (lit.)
Boling Point116 °C/22 mmHg (lit.)
Flash Point202°F
Water Solubilityimmiscible
Solubility Chloroform, Ethyl Acetate, Methanol
Vapor Presure3.09Pa at 25℃
AppearanceLiquid
Specific Gravity1.338
Colordeep greenish-yellow
BRN607262
Storage ConditionSealed in dry,Room Temperature
Refractive Indexn20/D 1.532(lit.)
Physical and Chemical PropertiesBoiling Point: 116 °c/22mmHg, Melting Point:-8 °c, Flash point: 14 °c, refractive index: 1.5317, specific gravity: 1.338.
UseUsed as pesticide, pharmaceutical and dye intermediates

2-NITROFLUOROBENZENE - Risk and Safety

Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S36/37 - Wear suitable protective clothing and gloves.
UN IDs2810
WGK Germany3
TSCAYes
HS Code29049085
Hazard NoteToxic/Irritant
Hazard Class6.1
Packing GroupIII

2-NITROFLUOROBENZENE - Upstream Downstream Industry

Raw Materials1-Chloro-2-nitrobenzene

2-NITROFLUOROBENZENE - Security information

dangerous goods mark Xi,T,Xn
hazard category code 36/37/38-20/21/22
safety instructions 26-36-36/37
dangerous goods transport number 2810
WGK Germany 3
Hazard Note Toxic/Irritant
TSCA Yes
HazardClass 6.1
PackingGroup III
customs code 29049085
Last Update:2024-04-10 22:29:15

2-NITROFLUOROBENZENE - Nature

melting point -9--6°C (lit.)
boiling point 116 °C/22 mmHg (lit.)
density 1.338 g/mL at 25°C (lit.)
refractive index n20/D 1.532(lit.)
flash point 202 °F
storage conditions Sealed in dry,Room Temperature
morphology Liquid
color deep greenish-yellow
Specific gravity 1.338
water solubility immiscible
BRN 607262
NIST chemical information Benzene, 1-fluoro-2-nitro-(1493-27-2)
EPA chemical information Benzene, 1-fluoro-2-nitro- (1493-27-2)
Last Update:2024-04-09 01:59:49

2-NITROFLUOROBENZENE - Uses and synthesis methods

introduction

1-fluoro-2-nitrobenzene, also called 2-fluoronitrobenzene, is a substituted nitrobenzene compound. Nitrobenzene compounds are a kind of chemical intermediates with a wide range of uses. Substituted nitrobenzene is reduced to obtain substituted aniline, which can be easily converted into various aromatic derivatives.

preparation

choline chloride (0.28g,2mmol) and urea (0.12g,2mmol) were prepared into eutectic, o-chloronitrobenzene (2mmol), potassium fluoride (10mmol) and DMSO(2.5ml) were added, heated to 160 ℃ for 8 hours. Cooling to room temperature, adding 10ml of water, fully stirring, adding ethyl acetate (10ml × 3) extraction water layer, combining organic layer, saturated salt water washing (10ml × 3) organic layer. MgSO4 was dried and spun to obtain the crude product, which was separated by column chromatography to obtain the product 1-fluoro-2-nitrobenzene.

chemical properties boiling point: 116 ℃/22mmHg, melting point:-8 ℃, flash point: 14 ℃, refractive index: 1.5317, specific gravity: 1.338.
use Used as an intermediate for pesticides, medicines and dyes
Last Update:2024-04-09 21:01:54

2-NITROFLUOROBENZENE - Reference Information

LogP1.69
NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
Introduction 1-fluoro-2-nitrobenzene, also called 2-fluoronitrobenzene, is a substituted nitrobenzene compound. Nitrobenzene compounds are a kind of chemical intermediates with a wide range of uses. Substituted nitrobenzene is reduced to obtain substituted aniline, which can be easily converted into various aromatic derivatives.
preparation choline chloride (0.28g,2mmol) and urea (0.12g,2mmol) are prepared into eutectic, o-chloronitrobenzene (2mmol), potassium fluoride (10mmol) and DMSO(2.5ml) are added, heated to 160 ℃ for 8 hours. Cool to room temperature, add 10ml of water, stir thoroughly, add ethyl acetate (10ml × 3) to extract water layer, merge organic layer, and wash (10ml × 3) organic layer with saturated salt water. MgSO4 was dried and spigated to obtain the crude product, which was separated by column chromatography to obtain the product 1-fluoro-2-nitrobenzene.
Use Used as an intermediate for pesticides, medicines and dyes
Last Update:2024-04-09 15:16:48
2-NITROFLUOROBENZENE
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View History
2-NITROFLUOROBENZENE
IODINE PENTOXIDE
DICHLOROBIS(BENZONITRILE)PLATINUM (II)
AKOS BC-0729
POTASSIUM 3-INDOLEACETATE
Methyl
META PHENYLENE DIAMINE - FLAKE
Dolastatin 10 (NSC-376128)
10403-47-1
84677-06-5
Raw Materials for 2-NITROFLUOROBENZENE
1-Chloro-2-nitrobenzene
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