| Name | 1-Fluoro-2-nitrobenzene |
| Synonyms | Fluoronitrobenzene1 O-NITROFLUOROBENZENE O-FLUORONITROBENZENE 2-flouromitrobrnzene 2-Fluoronitrobenzene 2-NITROFLUOROBENZENE Olanzapine Impurity 2 Olanzapine Impurity 14 1-fluoro-2-nitro-benzen 1-Fluoro-2-nitrobenzene Benzene, o-nitrofluoro- 1- fluorine-2- nitrobenzene Adjacent fluoro nitrobenzene (3-fluoro-4-methoxyphenyl)boronic acid 1-fluoro-2-nitro-benzene radical anion |
| CAS | 1493-27-2 |
| EINECS | 216-088-0 |
| InChI | InChI=1/C7H8BFO3/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4,10-11H,1H3 |
| Molecular Formula | C6H4FNO2 |
| Molar Mass | 141.1 |
| Density | 1.338 g/mL at 25 °C (lit.) |
| Melting Point | -9--6 °C (lit.) |
| Boling Point | 116 °C/22 mmHg (lit.) |
| Flash Point | 202°F |
| Water Solubility | immiscible |
| Solubility | Chloroform, Ethyl Acetate, Methanol |
| Vapor Presure | 3.09Pa at 25℃ |
| Appearance | Liquid |
| Specific Gravity | 1.338 |
| Color | deep greenish-yellow |
| BRN | 607262 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.532(lit.) |
| Physical and Chemical Properties | Boiling Point: 116 °c/22mmHg, Melting Point:-8 °c, Flash point: 14 °c, refractive index: 1.5317, specific gravity: 1.338. |
| Use | Used as pesticide, pharmaceutical and dye intermediates |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29049085 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
| Raw Materials | 1-Chloro-2-nitrobenzene |
| dangerous goods mark | Xi,T,Xn |
| hazard category code | 36/37/38-20/21/22 |
| safety instructions | 26-36-36/37 |
| dangerous goods transport number | 2810 |
| WGK Germany | 3 |
| Hazard Note | Toxic/Irritant |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| customs code | 29049085 |
| melting point | -9--6°C (lit.) |
| boiling point | 116 °C/22 mmHg (lit.) |
| density | 1.338 g/mL at 25°C (lit.) |
| refractive index | n20/D 1.532(lit.) |
| flash point | 202 °F |
| storage conditions | Sealed in dry,Room Temperature |
| morphology | Liquid |
| color | deep greenish-yellow |
| Specific gravity | 1.338 |
| water solubility | immiscible |
| BRN | 607262 |
| NIST chemical information | Benzene, 1-fluoro-2-nitro-(1493-27-2) |
| EPA chemical information | Benzene, 1-fluoro-2-nitro- (1493-27-2) |
| introduction |
1-fluoro-2-nitrobenzene, also called 2-fluoronitrobenzene, is a substituted nitrobenzene compound. Nitrobenzene compounds are a kind of chemical intermediates with a wide range of uses. Substituted nitrobenzene is reduced to obtain substituted aniline, which can be easily converted into various aromatic derivatives. |
| preparation |
choline chloride (0.28g,2mmol) and urea (0.12g,2mmol) were prepared into eutectic, o-chloronitrobenzene (2mmol), potassium fluoride (10mmol) and DMSO(2.5ml) were added, heated to 160 ℃ for 8 hours. Cooling to room temperature, adding 10ml of water, fully stirring, adding ethyl acetate (10ml × 3) extraction water layer, combining organic layer, saturated salt water washing (10ml × 3) organic layer. MgSO4 was dried and spun to obtain the crude product, which was separated by column chromatography to obtain the product 1-fluoro-2-nitrobenzene. |
| chemical properties | boiling point: 116 ℃/22mmHg, melting point:-8 ℃, flash point: 14 ℃, refractive index: 1.5317, specific gravity: 1.338. |
| use | Used as an intermediate for pesticides, medicines and dyes |
| LogP | 1.69 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Introduction | 1-fluoro-2-nitrobenzene, also called 2-fluoronitrobenzene, is a substituted nitrobenzene compound. Nitrobenzene compounds are a kind of chemical intermediates with a wide range of uses. Substituted nitrobenzene is reduced to obtain substituted aniline, which can be easily converted into various aromatic derivatives. |
| preparation | choline chloride (0.28g,2mmol) and urea (0.12g,2mmol) are prepared into eutectic, o-chloronitrobenzene (2mmol), potassium fluoride (10mmol) and DMSO(2.5ml) are added, heated to 160 ℃ for 8 hours. Cool to room temperature, add 10ml of water, stir thoroughly, add ethyl acetate (10ml × 3) to extract water layer, merge organic layer, and wash (10ml × 3) organic layer with saturated salt water. MgSO4 was dried and spigated to obtain the crude product, which was separated by column chromatography to obtain the product 1-fluoro-2-nitrobenzene. |
| Use | Used as an intermediate for pesticides, medicines and dyes |