2-NBDG
2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose
CAS: 186689-07-6
Molecular Formula: C12H14N4O8
2-NBDG - Names and Identifiers
2-NBDG - Physico-chemical Properties
| Molecular Formula | C12H14N4O8 |
| Molar Mass | 342.26 |
| Density | 1.750±0.06 g/cm3(Predicted) |
| Melting Point | 137 - 140°C |
| Boling Point | 740.0±70.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 10 mg/ml). |
| Appearance | solid |
| Color | Dark yellow to orange/red |
| BRN | 7603370 |
| pKa | 12.96±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Physical and Chemical Properties | Bioactive 2-NBDG, a fluorescent deoxyglucose derivative, is a marker for detecting glucose uptake and is also used to detect cell viability. |
| In vitro study | It has since been demonstrated in living mammalian cells that the uptake of 2-NBDG takes place through glucose transporters (GLUTs) in a concentration-, time- and temperature-dependent manner. A short-period application of 2-NBDG produced a remarkable increase in the fluorescence intensity in COS-1 cells over-expressing GLUT2, whereas the increase was barely detectable in mock-transfected cells. In mouse insulin-secreting clonal MIN6 cells, uptake was inhibited by cytochalasin B, a specific blocker for GLUTs, and by D-glucose in a dose-dependent manner. |
2-NBDG - Risk and Safety
| WGK Germany | 3 |
2-NBDG - Reference
| Reference Show more | 1. [IF=4.192] Jing Xu et al."Dietary Ginsenoside T19 Supplementation Regulates Glucose and Lipid Metabolism via AMPK and PI3K Pathways and Its Effect on Intestinal Microbiota."J Agr Food Chem. 2020;68(49):14452–14462 |
2-NBDG - Uses and synthesis methods
in vitro studies
It has since been demonstrated in living mammalian cells that the uptake of 2-NBDG takes place through glucose transporters (GLUTs) in a concentration-, time- and temperature-dependent manner. A short-period application of 2-NBDG produced a remarkable increase in the fluorescence intensity in COS-1 cells over-expressing GLUT2, whereas the increase was barely detectable in mock-transfected cells. In mouse insulin-secreting clonal MIN6 cells, uptake was inhibited by cytochalasin B, a specific blocker for GLUTs, and by D-glucose in a dose-dependent manner.
Last Update：2024-04-09 21:01:54
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Product Name: (2R,3R,4S,5R)-3,4,5,6-Tetrahydroxy-2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanal Request for quotationCAS: 186689-07-6
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Product Name: (2R,3R,4S,5R)-3,4,5,6-Tetrahydroxy-2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanal Visit Supplier Webpage Request for quotationCAS: 186689-07-6
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