2-Hydroxy-5-nitroaniline
2-Amino-4-nitrophenol
CAS: 99-57-0
Molecular Formula: C6H6N2O3
2-Hydroxy-5-nitroaniline - Names and Identifiers
| Name | 2-Amino-4-nitrophenol |
| Synonyms | 4-NAP rodol42 nci-c55958 C.I. 76530 p-nitroaminofenol P-NITRO-O-AMINOPHENOL 2-AMINO-4-NITROPHENOL 2-Amino-4-nitrophenol 4-Nitro-2-Aminophenol 2-amino-4-nitrophenolate 2-Hydroxy-5-nitroaniline 3-AMINO-4-HYDROXYNITROBENZENE 3-Amino-4-hydroxynitrobenzene p-Nitro-o-aminophenol 4-Nitro-2-aminophenol |
| CAS | 99-57-0 |
| EINECS | 202-767-9 |
| InChI | InChI=1/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2 |
2-Hydroxy-5-nitroaniline - Physico-chemical Properties
| Molecular Formula | C6H6N2O3 |
| Molar Mass | 154.12 |
| Density | 1.3617 (estimate) |
| Melting Point | 140-143 °C (lit.) |
| Boling Point | 322.46°C (rough estimate) |
| Flash Point | 100 °C |
| Water Solubility | slightly soluble |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.005Pa at 25℃ |
| Appearance | Solid |
| Color | Dark Yellow to Brown |
| BRN | 776533 |
| pKa | 6.82±0.22(Predicted) |
| Storage Condition | Refrigerator, Under Inert Atmosphere |
| Refractive Index | 1.6890 (rough estima |
| Physical and Chemical Properties | Characteristics of Brown yellow or orange crystals. melting point 80~90 ℃ solubility: soluble in acetic acid, ethanol and acetic acid, slightly soluble in water. |
| Use | Used as a dye and pharmaceutical intermediates |
2-Hydroxy-5-nitroaniline - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects R43 - May cause sensitization by skin contact R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| UN IDs | 2811 |
| WGK Germany | 2 |
| RTECS | SJ6300000 |
| TSCA | Yes |
| HS Code | 29071990 |
| Hazard Note | Irritant |
2-Hydroxy-5-nitroaniline - Nature
Open Data Verified Data
brown or orange Flake crystals. A water melting point of 80~90 deg C, anhydrous melting point of 145~147 deg C (142~143 deg C; 195~198 deg C decomposition). Soluble in acetic acid, ethanol and ether, slightly soluble in water.
Last Update：2024-01-02 23:10:35
2-Hydroxy-5-nitroaniline - Application
Open Data Verified Data
dye intermediates, direct dyes and reactive dyes can be synthesized.
Last Update：2025-08-19 16:24:40
2-Hydroxy-5-nitroaniline - Safety
Open Data Verified Data
- toxic. Detailed toxicity was not reported. See nitrobenzene and phenol for toxicity and protection methods.
- The container was packed with an iron drum lined with a plastic bag. 50kg per barrel. Store in a dry, ventilated place to avoid sun exposure and prevent heat and moisture. storage and transportation according to toxic chemicals
Last Update：2025-06-10 22:55:16
2-Hydroxy-5-nitroaniline - Reference Information
| LogP | 1.26 |
| (IARC) carcinogen classification | 3 (Vol. 57) 1993 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | for the manufacture of reactive dyes, acid dyes, neutral dyes and Solvent dyes, etc. as dyes and pharmaceutical intermediates. For acid-borne Brown RH; Neutral black BL, BRL, BGL, etc. used as dye and pharmaceutical intermediates as pesticide and pharmaceutical intermediates |
| production method | prepared by hydrolysis of 2, 4-dinitrochlorobenzene and partial reduction of sodium polysulfide. Raw material consumption quota: 2, 4-dinitrochlorobenzene (industrial) 2100kg/t, liquid alkali (40%)2050kg/t, sodium polysulfide (100%)700kg/t, hydrochloric acid (37%)150kg/t. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2400 mg/kg; Oral-mouse LD50: 850 mg/kg |
| stimulation data | eyes-rabbits 100 mg/24 h moderate |
| flammability hazard characteristics | open flame flammable; Thermal decomposition of toxic nitrogen oxide gases |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | carbon dioxide, sand, foam, dry powder |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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