2-Chlorbenzoesαure
2-Chlorobenzoic acid
CAS: 118-91-2
Molecular Formula: C7H5ClO2
2-Chlorbenzoesαure - Names and Identifiers
| Name | 2-Chlorobenzoic acid |
| Synonyms | OCBA 2-CBA 2-chlorobenzoic 2-Chlorbenzoesαure 2-chloro-benzoicaci RARECHEM AL BO 0021 O-CHLOROBENZOIC ACID 2-Chlorobenzoic acid |
| CAS | 118-91-2 |
| EINECS | 204-285-4 |
| InChI | InChI=1/C7H5ClO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)/p-1 |
| InChIKey | IKCLCGXPQILATA-UHFFFAOYSA-N |
2-Chlorbenzoesαure - Physico-chemical Properties
| Molecular Formula | C7H5ClO2 |
| Molar Mass | 156.57 |
| Density | 1.544 |
| Melting Point | 139-143℃ |
| Boling Point | 275.7°C at 760 mmHg |
| Flash Point | 120.5°C |
| Water Solubility | soluble in hot water |
| Solubility | Soluble in alcohol and ether, soluble in 900 parts of cold water, more soluble in hot water, insoluble in toluene. |
| Vapor Presure | 0.00242mmHg at 25°C |
| Appearance | Morphology Powder |
| Color | White to off-white |
| Merck | 14,2124 |
| BRN | 907340 |
| pKa | 2.92(at 25℃) |
| PH | 3.4 (0.2g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable, combustible. Incompatible with strong bases, strong oxidizing agents. |
| Refractive Index | 1.5812 (estimate) |
| MDL | MFCD00002412 |
| Physical and Chemical Properties | The character is close to white coarse powder. melting point 142 ℃ relative density 1.544g/cm3 solubility: insoluble in water, 95% ethanol solution and toluene solution, soluble in methanol, anhydrous ethanol, ethyl ether, acetone and benzene. |
| Use | Is a pharmaceutical, pesticide intermediates, mainly used for the preparation of chlorpromazine, anti-inflammatory, diclofenac and other drugs, but also for dyes and color film |
2-Chlorbenzoesαure - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 2 |
| RTECS | DG4976000 |
| TSCA | Yes |
| HS Code | 29163900 |
| Toxicity | LD50 orally in Rabbit: 2465 mg/kg |
2-Chlorbenzoesαure - Upstream Downstream Industry
2-Chlorbenzoesαure - Nature
Open Data Verified Data
close to white coarse powder. Melting point 142 °c. Density (20 ° C) 1.544g/cm3, sublimation, no boiling point, insoluble in water, 95% ethanol solution and toluene solution, soluble in methanol, ethanol, ether, acetone and benzene.
Last Update：2025-06-10 22:55:16
2-Chlorbenzoesαure - Preparation Method
Open Data Verified Data
- O-aminobenzoic acid was prepared by amidation and degradation of phthalic anhydride with sodium hydroxide and ammonia water, and then diazotized with sodium nitrite and hydrochloric acid, and then cuprous chloride, hydrochloric acid replacement and preparation of O-chlorobenzoic acid crude, after refined to the finished product.
- O-chlorotoluene was obtained by direct oxidation.
- O-chlorotoluene was obtained by hydrolysis and chlorination.
Last Update：2022-01-01 10:43:23
2-Chlorbenzoesαure - Introduction
Easy to sublimate. It's irritating.
Last Update：2022-10-16 17:12:28
2-Chlorbenzoesαure - Application
Open Data Verified Data
dye, pesticide intermediates, medicine is the raw material of chlorpromazine and anti-inflammatory, also used as adhesives and coatings of preservatives, can also be used as fungicides and organic synthesis of raw materials.
Last Update：2025-08-19 16:24:40
2-Chlorbenzoesαure - Safety
Open Data Verified Data
- This product is toxic, its toxicity and protection see benzoic acid. Mice were injected subcutaneously with LD501200mg/kg.
- The bag is lined with plastic bag. 50kg per bag. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:43:23
2-Chlorbenzoesαure - Security information
| WGK Germany | 2 |
| RTECS number | DG4976000 |
| auto-ignition temperature | 530 °C |
| Hazard Note | Irritant |
| TSCA | Yes |
| customs code | 29163900 |
| toxic substance data | 118-91-2(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 2465 mg/kg |
Last Update：2024-04-10 22:29:15
2-Chlorbenzoesαure - Nature
| storage conditions | Store below 30°C. |
| solubility | cold water: soluble900 part |
| acidity coefficient (pKa) | 2.92(at 25℃) |
| morphology | Powder |
| color | White to off-white |
| PH value | 3.4 (0.2g/l, H2O, 20℃) |
| water solubility | soluble in hot water |
| Merck | 14,2124 |
| BRN | 907340 |
| stability | Stable, combustible. Incompatible with strong bases, strong oxidizing agents. |
| InChIKey | IKCLCGXPQILATA-UHFFFAOYSA-N |
| NIST chemical information | Benzoic acid, 2-chloro-(118-91-2) |
| EPA chemical information | o-Chlorobenzoic acid (118-91-2) |
Last Update：2024-04-09 01:59:49
2-Chlorbenzoesαure - Uses and synthesis methods
production method
1. phthalic anhydride is used as raw material, sodium hydroxide and ammonia are used for amidation and degradation reaction to prepare anthranilic acid, and then sodium nitrite and hydrochloric acid are used for diazotization, and then cuprous chloride and hydrochloric acid are used. Replacement to prepare crude o-chlorobenzoic acid, which is refined to obtain the finished product. 2. It is prepared by direct oxidation of o-chlorotoluene. 3. It is prepared by chlorination and hydrolysis of o-chlorotoluene.
2. there are the following two preparation methods.
chlorinated hydrolysis of o-chlorotoluene
O-chlorotoluene is placed in a reaction kettle, illuminated with ultraviolet lamp, the reaction temperature is 100 ℃, chlorine gas is introduced to carry out chlorination reaction, and the depth of chlorination reaction is deepened to generate α,α,α, 2-tetrachlorotoluene, or using o-chlorotoluene as raw material and azobisisobutyronitrile as catalyst for chlorination, α,α, 2-tetrachlorot, add a little acid to hydrolyze it to produce o-chlorobenzoyl chloride. If the depth of hydrolysis is large, 2-chlorobenzoic acid can be obtained.
Diazotization of anthranilic acid
hydrochloric acid and sodium nitrite are added to anthranilic acid as raw material for diazotization, and then Cu2Cl2 solution in hydrochloric acid is added to diazonium solution, stirring while adding, and o chlorobenzoic acid is obtained after post-treatment.
category
Toxic substances
toxicity classification
low toxicity
acute toxicity
oral-rat LD50: 6460 mg/kg; Abdominal-mouse LD50: 2300 mg/kg
stimulus data
skin-rabbit 500 mg/24 hours mild; eyes-rabbit 20 mg/24 hours moderate
flammability hazard characteristics
Thermal decomposition discharges toxic chloride fumes
storage and transportation features
Warehouse low temperature ventilation and drying
fire extinguishing agent
Water, carbon dioxide, foam, dry powder
Last Update：2024-04-09 18:58:34
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View History
Raw Materials for 2-Chlorbenzoesαure
Downstream Products for 2-Chlorbenzoesαure
2-Chlorobenzoyl chloride
chlorbenzuron
Ketamine hydrochloride
Diclofenac sodium
9(10H)-ACRIDONE
2-Chlorophenyl cyclopentyl ketone
Clofenamic acid
3-CHLORODIPHENYLAMINE
chlorbenzuron
Ketamine hydrochloride
Diclofenac sodium
9(10H)-ACRIDONE
2-Chlorophenyl cyclopentyl ketone
Clofenamic acid
3-CHLORODIPHENYLAMINE