1978-39-8
5-Fluoro-2-methoxyaniline
CAS: 1978-39-8
Molecular Formula: C7H8FNO
1978-39-8 - Names and Identifiers
1978-39-8 - Physico-chemical Properties
| Molecular Formula | C7H8FNO |
| Molar Mass | 141.14 |
| Density | 1.1981 g/mL at 25 °C |
| Melting Point | 3 °C |
| Boling Point | 90 °C/760 mmHg |
| Flash Point | 109°C |
| Vapor Presure | 0.0532mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow to Light orange |
| pKa | 3.52±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | n20/D 1.5438 |
1978-39-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2810 6.1/PG III |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| Packing Group | III |
1978-39-8 - Introduction
5-Fluoro-2-methoxyaniline, chemical formula C7H8FNO, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: colorless or slightly yellow crystal.
2. Melting Point: about 58-62 ℃.
3. Boiling point: About 203 ℃.
4. Density: 1.149 g/mL.
5. Solubility: Soluble in some organic solvents, such as ethanol and chloroform.
Use:
1. 5-Fluoro-2-methoxyaniline is a common intermediate in organic synthesis. It plays an important role in the preparation of other organic compounds.
2. The compound is also used as an intermediate in the pharmaceutical field, mainly for the synthesis of drugs.
Method:
A common method for preparing 5-Fluoro-2-methoxyaniline is as follows:
1.2-fluoro-cresol is generated by the reaction of phenol with sodium hydrogen 2-fluoromethanesulfonate.
2. 2-Fluoro-cresol is then reacted with methoxy bromide to obtain 5-Fluoro-2-methoxyaniline.
Safety Information:
1. 5-Fluoro-2-methoxyaniline is an organic fluorine compound and should be handled with caution.
2. When operating should follow the safety procedures, wear appropriate personal protective equipment, such as gloves and safety glasses.
3. Avoid inhaling its vapors or contact with skin and eyes.
4. When storing, it should be stored in a closed container, away from fire and oxidant.
Please note that before using or handling 5-Fluoro-2-methoxyaniline, please refer to the laboratory chemical safety manual and follow the relevant safety operating procedures.
Nature:
1. Appearance: colorless or slightly yellow crystal.
2. Melting Point: about 58-62 ℃.
3. Boiling point: About 203 ℃.
4. Density: 1.149 g/mL.
5. Solubility: Soluble in some organic solvents, such as ethanol and chloroform.
Use:
1. 5-Fluoro-2-methoxyaniline is a common intermediate in organic synthesis. It plays an important role in the preparation of other organic compounds.
2. The compound is also used as an intermediate in the pharmaceutical field, mainly for the synthesis of drugs.
Method:
A common method for preparing 5-Fluoro-2-methoxyaniline is as follows:
1.2-fluoro-cresol is generated by the reaction of phenol with sodium hydrogen 2-fluoromethanesulfonate.
2. 2-Fluoro-cresol is then reacted with methoxy bromide to obtain 5-Fluoro-2-methoxyaniline.
Safety Information:
1. 5-Fluoro-2-methoxyaniline is an organic fluorine compound and should be handled with caution.
2. When operating should follow the safety procedures, wear appropriate personal protective equipment, such as gloves and safety glasses.
3. Avoid inhaling its vapors or contact with skin and eyes.
4. When storing, it should be stored in a closed container, away from fire and oxidant.
Please note that before using or handling 5-Fluoro-2-methoxyaniline, please refer to the laboratory chemical safety manual and follow the relevant safety operating procedures.
Last Update：2024-04-09 15:17:54
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