19755-53-4
2-Bromo-3-nitropyridine
CAS: 19755-53-4
Molecular Formula: C5H3BrN2O2
19755-53-4 - Names and Identifiers
| Name | 2-Bromo-3-nitropyridine |
| Synonyms | 2-BroMo-3-nitropyrid 2-BROMO-3-NITROPYRIDINE 2-Bromo-3-nitropyridine 2-bromo-3-nitro pyridine Pyridine, 2-bromo-3-nitro- 2-Bromo-3-nitropyridine in stock Factory |
| CAS | 19755-53-4 |
| EINECS | 625-152-0 |
| InChI | InChI=1/C5H3BrN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H |
| InChIKey | ZCCUFLITCDHRMG-UHFFFAOYSA-N |
19755-53-4 - Physico-chemical Properties
| Molecular Formula | C5H3BrN2O2 |
| Molar Mass | 202.99 |
| Density | 1.8727 (rough estimate) |
| Melting Point | 122-125 °C (lit.) |
| Boling Point | 244.0±20.0 °C(Predicted) |
| Flash Point | 101.4°C |
| Vapor Presure | 0.0485mmHg at 25°C |
| Appearance | White-like powder |
| BRN | 124504 |
| pKa | -3.24±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.6200 (estimate) |
| MDL | MFCD00955613 |
19755-53-4 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
19755-53-4 - Reference Information
| Properties | 2-bromo-3-nitropyridine is gray-white to cream-colored crystalline powder at room temperature and pressure. It is a pyridine derivative and has the general properties of the pyridine ring. |
| Use | 2-bromo-3-nitropyridine can be used as an intermediate in pharmaceutical chemistry and organic synthesis. In the synthesis and transformation, the nitro group on the pyridine ring can be reduced to amino group; affected by the electron-deficient properties of the pyridine ring and the strong electron-withdrawing properties of the nitro group, the bromine atom in the structure can be easily attacked by nucleophiles such as alkylamines or oxygen anions to obtain further derivatized products. |
| synthesis method | 48% hydrobromic acid (2.31 ml, 20 mmol) solution dissolved in dimethyl sulfoxide (25 ml) is added dropwise to 2-amino -3-nitropyridine ((0.986g, 5 mmol) in a mixed system of 25 ml dimethyl sulfoxide and potassium nitrite (0.851g, 10 mmol), the resulting mixture was stirred at 35°C and then transferred to a solution containing potassium carbonate (5g) in 100 ml of ice water, then the reaction mixture was dissolved in ether, the ether extract was washed with water and dried with anhydrous magnesium sulfate. Remove the organic solvent under reduced pressure to obtain crude 4-bromobenzophenone. The crude product was further purified by column chromatography to obtain 2-bromo-3-nitropyridine. Figure 2-Bromo-3-nitropyridine synthesis route |
Last Update：2024-04-09 21:04:16
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