196868-63-0
PQ 401
CAS: 196868-63-0
Molecular Formula: C18H16ClN3O2
196868-63-0 - Names and Identifiers
196868-63-0 - Physico-chemical Properties
| Molecular Formula | C18H16ClN3O2 |
| Molar Mass | 341.79 |
| Density | 1.370±0.06 g/cm3 (20 ºC 760 Torr) |
| Solubility | 25°C: DMSO 32 mg/mL (93.62 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM) |
| Appearance | White solid |
| Color | white |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00160558 |
| Use | An inhibitor of IGF-1R autophosphorylation. |
| In vitro study | PQ 401 is a IGF-1R inhibitor, and inhibits the phosphorylation of the kinase domain by IGF-IR at a concentration of <100 nM, with an IC50 < 1 μm. PQ 401 significantly reduces MCF-7 cell proliferation with an IC50 of 8 μm. PQ 401 also inhibited the growth of MCNeuA cells with an IC50 of 15 μm. PQ 401 acts on MCF-7 cells and inhibits IGF-I of the regulated anti-apoptotic pathway. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity. PQ 401 is a IGF-1R inhibitor that inhibits the autophosphorylation of the kinase domain by IGF-IR at concentrations <100 nM with an IC50 < 1 μm. PQ 401 significantly reduced the proliferation of MCF-7 cells with IC50 of 8 μm. PQ 401 also inhibited the growth of MCNeuA cells with an IC50 of 15 μm. PQ 401 acts on MCF-7 cells and inhibits IGF-I of the regulated anti-apoptotic pathway. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity. |
| In vivo study | PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth in a dose-dependent manner. PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth in a dose-dependent manner. |
196868-63-0 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
196868-63-0 - Introduction
PQ 401 inhibited autophosphorylation in the IGF-1R region with an IC50 of less than 1 μM.
Last Update：2022-10-16 17:41:31
196868-63-0 - Reference Information
| biological activity | PQ 401 inhibits autophosphorylation of IGF-1R region, IC50 is less than 1 μM. PQ 401 inhibits autophosphorylation of IGF-1R region with IC50 less than 1 μM. |
| in vitro study | PQ 401 is a IGF-1R inhibitor. when the concentration is <100 nM, it inhibits autophosphorylation of IGF-IR kinase domain, IC50 < 1 μM. PQ 401 significantly reduces MCF-7 cell proliferation, IC50 is 8 μM. PQ 401 also inhibited MCNeuA cell growth with an IC50 of 15 μM. PQ 401 acts on MCF-7 cells and inhibits IGF-I-regulated anti-apoptotic pathways. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity. PQ 401 is a IGF-1R inhibitor. when the concentration is <100 nM, it inhibits autophosphorylation of IGF-IR kinase domain, IC50 < 1 μM. PQ 401 significantly reduces MCF-7 cell proliferation, IC50 is 8 μM. PQ 401 also inhibited MCNeuA cell growth with an IC50 of 15 μM. PQ 401 acts on MCF-7 cells and inhibits IGF-I-regulated anti-apoptotic pathways. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity. |
| in vivo study | PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth, which is dose-dependent. PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth in a dose-dependent manner. |
| target | TargetValue IGF-1R <1 μM |
| Target | Value |
| IGF-1R | <1 μM |
Last Update：2024-04-09 01:59:58
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Product Name: PQ401 Request for quotationCAS: 196868-63-0
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Mobile: 18916960931
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Mobile: +86-18621343501
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Tel: 609-228-6898
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Product Name: PQ 401 Visit Supplier Webpage Request for quotationCAS: 196868-63-0
Tel: 18301782025
Email: 3008007409@qq.com
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