182498-32-4
SB 225002
CAS: 182498-32-4
Molecular Formula: C13H10BrN3O4
182498-32-4 - Names and Identifiers
182498-32-4 - Physico-chemical Properties
| Molecular Formula | C13H10BrN3O4 |
| Molar Mass | 352.14 |
| Solubility | Soluble to 100mM in DMSO and to 50mM in ethanol |
| Appearance | Yellow solid |
| Color | white to beige |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Sensitive | Moisture Sensitive |
| In vitro study | In vitro experiments, SB225002 inhibited groα-stimulated calcium mobilization and effectively inhibited IL-8 and groα-induced chemotaxis of human and rabbit neutrophils. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. In an in vitro experiment, SB225002 inhibited groα-stimulated calcium mobilization and effectively inhibited IL-8 and groα-induced chemotaxis of human and rabbit neutrophils. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. |
| In vivo study | In rabbits, SB225002 selectively blocked IL-8-induced neutrophil flanking. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. In rabbits, SB225002 selectively blocked IL-8-induced neutrophil flanking. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. |
182498-32-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
182498-32-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.84 ml | 14.199 ml | 28.398 ml |
| 5 mM | 0.568 ml | 2.84 ml | 5.68 ml |
| 10 mM | 0.284 ml | 1.42 ml | 2.84 ml |
| 5 mM | 0.057 ml | 0.284 ml | 0.568 ml |
Last Update：2024-01-02 23:10:35
182498-32-4 - Reference Information
| biological activity | SB225002 is a potent and selective CXCR2 antagonist that inhibits the binding of interleukin IL-8 to CXCR2, the IC50 was 22 nM and the selectivity was more than 150-fold higher than the other 7-TMRs tested. SB225002 is a potent and selective CXCR2 antagonist that inhibits the binding of interleukin IL-8 to CXCR2 with an IC50 of 22 nM and is more than 150-fold more selective than the other 7-TMRs tested. |
| in vitro study | in vitro experiment, SB225002 inhibits calcium mobilization stimulated by GRO Alpha, and effectively inhibit the chemotaxis of human and rabbit neutrophils induced by IL-8 and groα. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. In an in vitro experiment, SB225002 inhibited groα-stimulated calcium mobilization and effectively inhibited IL-8 and groα-induced chemotaxis of human and rabbit neutrophils. SB 225002 substantially reduced the level of phosphorylated ERK1/2 and reduced cell differentiation in WHCO1 cells. SB225002 also exhibits anti-tumor activity as a microtubule inhibitor. |
| in vivo study | in rabbits, SB225002 selectively blocked IL-8-induced flanking of neutrophils. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. In rabbits, SB225002 selectively blocked IL-8-induced neutrophil flanking. SB225002 (1 mg/kg I. p.) inhibits the growth of subcutaneously implanted tumors in a mouse intrahepatic cholangiocarcinoma model. In addition, SB225002 also exhibited a long-acting anti-inflammatory effect and reduced TNBS-induced colitis in a mouse model. |
| Target | TargetValue CXCR2 (Cell-free assay) 22 nM |
| Target | Value |
| CXCR2 (Cell-free assay) | 22 nM |
Last Update：2024-04-10 22:29:15
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Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: SB225002 Visit Supplier Webpage Request for quotationCAS: 182498-32-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SB 225002 Request for quotationCAS: 182498-32-4
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Multiple SpecificationsSpot supply
Product Name: SB-225002 Request for quotationCAS: 182498-32-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea Visit Supplier Webpage Request for quotationCAS: 182498-32-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SB 225002 Visit Supplier Webpage Request for quotationCAS: 182498-32-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SB 225002 Visit Supplier Webpage Request for quotationCAS: 182498-32-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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