18108-24-2
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID
CAS: 18108-24-2
Molecular Formula: C4H12NO3P
18108-24-2 - Names and Identifiers
| Name | (1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID |
| Synonyms | (1-Amino-2-methylpropyl)phosponic acid. (1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID [(1R)-1-ammonio-2-methylpropyl]phosphonate [(1S)-1-ammonio-2-methylpropyl]phosphonate [(1R)-2-methyl-1-phosphonatopropyl]ammonium |
| CAS | 18108-24-2 |
| InChI | InChI=1/C4H12NO3P/c1-3(2)4(5)9(6,7)8/h3-4H,5H2,1-2H3,(H2,6,7,8)/p-1/t4-/m1/s1 |
18108-24-2 - Physico-chemical Properties
| Molecular Formula | C4H12NO3P |
| Molar Mass | 153.12 |
| Melting Point | 267-272 °C |
| Boling Point | 302.9°C at 760 mmHg |
| Flash Point | 137°C |
| Vapor Presure | 0.000223mmHg at 25°C |
| Appearance | solid |
18108-24-2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
18108-24-2 - Introduction
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is an organophosphorus compound commonly abbreviated as Me2P(O)NH2. The following is a description of its nature, use, preparation and safety information:
Nature:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is a colorless liquid with a pungent odor. It melts at room temperature and is soluble in organic solvents such as water, ethers and alcohols. It is a strong reducing agent that can react with oxygen and some oxidants.
Use:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is mainly used as a phosphine source in organic synthesis. It can be used as a phosphine ligand for metal-catalyzed reactions and participate in a variety of organic synthesis reactions. In addition, it can also be used as an organic deprotection reagent, and can remove amino protecting groups (such as t-propyl, benzyl, etc.).
Method:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is mainly prepared by the reaction dehydration of dialkylphosphonic ACID (such as dimethylphosphonic ACID) and amine. For example, dimethylphosphonic ACID is reacted with methylamine at higher temperatures to give (1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID.
Safety Information:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is irritating and corrosive, and care should be taken to avoid contact with skin and eyes. Wear appropriate personal protective equipment such as safety glasses, gloves and protective clothing when operating. During storage and use, it should be kept away from fire and oxidizing agents, kept closed and stored in a cool and dry place. If you have inhaled or come into contact with a large amount of a substance, you should seek medical advice immediately.
Nature:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is a colorless liquid with a pungent odor. It melts at room temperature and is soluble in organic solvents such as water, ethers and alcohols. It is a strong reducing agent that can react with oxygen and some oxidants.
Use:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is mainly used as a phosphine source in organic synthesis. It can be used as a phosphine ligand for metal-catalyzed reactions and participate in a variety of organic synthesis reactions. In addition, it can also be used as an organic deprotection reagent, and can remove amino protecting groups (such as t-propyl, benzyl, etc.).
Method:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is mainly prepared by the reaction dehydration of dialkylphosphonic ACID (such as dimethylphosphonic ACID) and amine. For example, dimethylphosphonic ACID is reacted with methylamine at higher temperatures to give (1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID.
Safety Information:
(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID is irritating and corrosive, and care should be taken to avoid contact with skin and eyes. Wear appropriate personal protective equipment such as safety glasses, gloves and protective clothing when operating. During storage and use, it should be kept away from fire and oxidizing agents, kept closed and stored in a cool and dry place. If you have inhaled or come into contact with a large amount of a substance, you should seek medical advice immediately.
Last Update：2024-04-09 20:52:54
