1667-11-4
4-(chloromethyl)biphenyl
CAS: 1667-11-4
Molecular Formula: C13H11Cl
1667-11-4 - Names and Identifiers
| Name | 4-(chloromethyl)biphenyl |
| Synonyms | 4CMB 4-cmb 4-Chloromethylbiphen p-phenylbenzylchloride 4-Chloromethylbiphenyl p-phenylbenzyl chloride 4-Chloromethyl Biphenyl p-Phenylbenzyl Chloride 4-(chloromethyl)-bipheny 4-(chloromethyl)biphenyl 4-BIPHENYLMETHYL CHLORIDE |
| CAS | 1667-11-4 |
| EINECS | 216-786-5 |
| InChI | InChI=1/C13H11Cl/c14-10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2 |
1667-11-4 - Physico-chemical Properties
| Molecular Formula | C13H11Cl |
| Molar Mass | 202.68 |
| Density | 1.1339 (estimate) |
| Melting Point | 70-73 °C (lit.) |
| Boling Point | 321.03°C (rough estimate) |
| Flash Point | 143.2°C |
| Vapor Presure | 0.000527mmHg at 25°C |
| BRN | 1863327 |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.5945 (estimate) |
| MDL | MFCD00000917 |
| Physical and Chemical Properties | Appearance white to off-white crystalline powder Content (HPLC) ≥ 95% |
1667-11-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DV2087000 |
| FLUKA BRAND F CODES | 21 |
| Hazard Class | IRRITANT |
1667-11-4 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| uses | 4-chloromethylbiphenyl is an important biphenyl derivative and has a wide range of uses in medicine, polymer liquid crystals, dyes, etc. For example, it can be used to synthesize non-steroidal anti-inflammatory drugs biphenylacetic acid, fenbufen, anti-inflammatory and analgesic diphenylacetate, etc. |
| application | 4-chloromethylbiphenyl is an important biphenyl derivative, which is widely used in medicine, polymer liquid crystal, dyes, etc. Examples of its application are as follows: Preparation of 4-biphenylacetic acid. 4-biphenylacetic acid molecular formula C14H12O2, molecular weight 212.24, white flake crystal. 4-Biphenylacetic acid is a non-steroidal anti-inflammatory drug, an effective metabolite of fenbufen, and has anti-inflammatory and analgesic activity similar to fenbufen. Indications are variant arthritis, scapulohumeral periarthritis, tenosynovitis, tendinitis, muscle pain, traumatic swelling, pain, etc. Its derivative ethyl biphenylacetate is also an anti-inflammatory analgesic, which is used to treat rheumatoid arthritis, low back pain, frozen shoulder, traumatic pain, and postoperative pain. It has a good effect, especially for the treatment of cancer pain. The preparation method is: using 4-chloromethylbiphenyl as raw material, in the presence of catalyst palladium dichloride, ligand triphenylphosphine, base, solvent, and carbon monoxide after carbonylation reaction, and then acidification, Separation to obtain 4-biphenylacetic acid. The method can be realized under the conditions of reaction temperature of 50-100 ℃ and pressure of 0.3-1.0MPa, with high reaction yield and less discharge of three wastes, which is suitable for industrial production. |
| category | toxic substances |
| flammability hazard characteristics | combustible, decomposition of toxic chloride gas during combustion |
| storage and transportation characteristics | warehouse low temperature, ventilation, drying |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 20:52:54
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