1620401-82-2
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
CAS: 1620401-82-2
Molecular Formula: C23H35N5O2
1620401-82-2 - Names and Identifiers
1620401-82-2 - Physico-chemical Properties
| Molecular Formula | C23H35N5O2 |
| Molar Mass | 413.56 |
| Density | 1.168±0.06 g/cm3(Predicted) |
| Boling Point | 606.3±65.0 °C(Predicted) |
| Solubility | Soluble in DMSO, not in water |
| Appearance | solid |
| Color | Tan |
| pKa | 10.54±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Use | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response. |
| In vitro study | UNC0379 is competitive with the peptide substrate and noncompetitive with the cofactor SAM. |
1620401-82-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.418 ml | 12.09 ml | 24.181 ml |
| 5 mM | 0.484 ml | 2.418 ml | 4.836 ml |
| 10 mM | 0.242 ml | 1.209 ml | 2.418 ml |
| 5 mM | 0.048 ml | 0.242 ml | 0.484 ml |
Last Update：2024-01-02 23:10:35
1620401-82-2 - Introduction
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is a compound with the chemical name N-((2,5-dioxy -1,4-phenyl) ethyl) acrylamide.
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is mainly used in biochemical and pharmaceutical research, in particular, it plays an important role in the study of epigenetic regulation. It is a small molecule compound that selectively inhibits the enzyme COMMD1, which plays a regulatory role in the process of DNA methylation in cells. The 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine can be used to study the effects of DNA methylation and may aid in the development of new cancer therapeutics.
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is generally produced by an organic synthesis method. Specific preparation methods may vary by manufacturer and research laboratory.
Regarding the safety information of 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, because it is a chemical substance, therefore, it is necessary to operate carefully in the laboratory and comply with safe operating procedures. It may have some potentially dangerous properties, such as irritation and toxicity. Therefore, when using 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, it is necessary to wear appropriate protective equipment such as gloves, glasses and laboratory coats, avoid contact with skin, eyes and mouth. In addition, it should be used in a well-ventilated place, properly dispose of waste after use, and comply with relevant laws and regulations. For specific safe operation and storage information, reference should be made to the safety data sheets provided by the supplier. Before using the 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, it is recommended to consult a professional for more detailed and accurate information.
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is mainly used in biochemical and pharmaceutical research, in particular, it plays an important role in the study of epigenetic regulation. It is a small molecule compound that selectively inhibits the enzyme COMMD1, which plays a regulatory role in the process of DNA methylation in cells. The 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine can be used to study the effects of DNA methylation and may aid in the development of new cancer therapeutics.
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is generally produced by an organic synthesis method. Specific preparation methods may vary by manufacturer and research laboratory.
Regarding the safety information of 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, because it is a chemical substance, therefore, it is necessary to operate carefully in the laboratory and comply with safe operating procedures. It may have some potentially dangerous properties, such as irritation and toxicity. Therefore, when using 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, it is necessary to wear appropriate protective equipment such as gloves, glasses and laboratory coats, avoid contact with skin, eyes and mouth. In addition, it should be used in a well-ventilated place, properly dispose of waste after use, and comply with relevant laws and regulations. For specific safe operation and storage information, reference should be made to the safety data sheets provided by the supplier. Before using the 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, it is recommended to consult a professional for more detailed and accurate information.
Last Update：2024-04-09 21:54:55
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Product Name: UNC0379 Visit Supplier Webpage Request for quotationCAS: 1620401-82-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: UNC0379 Request for quotationCAS: 1620401-82-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: UNC0379 Visit Supplier Webpage Request for quotationCAS: 1620401-82-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: UNC0379 Visit Supplier Webpage Request for quotationCAS: 1620401-82-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine Visit Supplier Webpage Request for quotation
CAS: 1620401-82-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1620401-82-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
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