161024-80-2

161024-80-2 - Names and Identifiers

Name	(R)-N-BOC-3-Amino-3-phenylpropanoic acid
Synonyms	Boc-R-PHA BOC-BETA-PHE-OH Boc-beta-Phe-OH BOC-PHG-(C*CH2)OH (R)-Boc-beta-Phe-OH BOC PROTECTED (R)-B-PHENYLALANINE (R)-N-BOC-beta-phenyl-beta-alanine Boc-R-3-Amino-3-phenylpropionic acid Boc-D-3-Amino-3-phenylpropionic acid BOC-(R)-3-AMINO-3-PHENYLPROPANOIC ACID BOC-(R)-3-AMINO-3-PHENYLPROPIONIC ACID Boc-(R)-3-amino-3-phenylpropionic acid (R)-N-Boc-3-Amino-3-phenylpropanoic acid (R)-N-BOC-3-Amino-3-phenylpropanoic acid (3R)-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate (R)-N-tert-Butoxycarbonyl-3-amino-3-phenylpropanoic acid (3R)-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoic acid (3R)-3-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoic acid
CAS	161024-80-2
InChI	InChI=1/C14H19NO4/c1-14(2,3)19-13(18)15-11(9-12(16)17)10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m1/s1

161024-80-2 - Physico-chemical Properties

Molecular Formula	C14H19NO4
Molar Mass	265.31
Density	1.1356 (rough estimate)
Melting Point	123.4 °C
Boling Point	408.52°C (rough estimate)
Flash Point	209.8°C
Vapor Presure	6.42E-08mmHg at 25°C
Appearance	Powder
Color	White
BRN	5404389
pKa	4.32±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5110 (estimate)

161024-80-2 - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29242990
Hazard Class	IRRITANT

161024-80-2 - Reference Information

use

(R)-Boc-beta-phenylalanine is an amino acid derivative and can be used as an organic intermediate.

preparation

(R)-3-amino -3-phenylpropionic acid (2.1g, 12.7 mmol, 1.0 equiv.) and NaHCO3 (1.6g, 19
mmol, 1.5 equiv.) were dissolved in water (30 mL). Dioxane (30 mL) and [(CH3)3CO2C]2O (4.1g,
19 mmol, 1.5 equiv.) were added to the reaction mixture. The solution was stirred at room temperature for 8 hours. The complete conversion of (R)-3-amino-3-phenylpropionic acid was confirmed by TLC (SiO2, 50/25/25
n-BuOH/HOAc/H2O). Remove the solvent by rotary evaporation. Distribute the crude mixture between HCl (1%) and EtOAc
. The water layer was extracted with EtOAc. The combined organic extracts were dried with Na2SO4. Filter and concentrate the solvent. The crude product was purified by column chromatography and eluted with 10%
CH3OH/DCM to obtain (R)-Boc-beta-phenylalanine.

Last Update：2024-04-10 22:29:15

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