158588-04-6
2-methyl-6-[(trimethylsilyl)methyl]-Pyridine
CAS: 158588-04-6
Molecular Formula: C10H17NSi
158588-04-6 - Names and Identifiers
158588-04-6 - Physico-chemical Properties
| Molecular Formula | C10H17NSi |
| Molar Mass | 179.33 |
158588-04-6 - Introduction
2-methyl-6-[(trimethylsilyl)methyl]-Pyridine (abbreviation: TMS-Py) is an organic compound whose chemical formula is C14H27NSi. It has the following properties:
1. Appearance: The TMS-Py is a colorless to light yellow liquid with a special smell.
2. Solubility: TMS-Py dissolves in many organic solvents.
3. Stability: TMS-Py is relatively stable at room temperature, but affected by light and oxygen in the air, it is prone to condensation, oxidation and other reactions.
The main uses of the TMS-Py are as follows:
1. Organic Synthesis Reagents: TMS-Py in organic synthesis as an important reagent. It can be used to synthesize compounds, such as amides, ethyl carboxylates, and so on.
2. Catalyst: TMS-Py, as a ligand of copper, can coordinate with copper ions to form a complex, which has a catalytic effect. In organic synthesis reactions, TMS-Py complexes can be used to catalyze cyclization reactions, substitution reactions of alkyl halides, etc.
There are many methods for preparing TMS-Py, and a common method is as follows:
Benzonitrile is reacted with trimethylsilyl magnesium chloride to obtain dimethylchlorosilicyl phenyl palladium, and then reacted with pyridine to obtain TMS-Py.
When using the TMS-Py, you need to pay attention to the following safety matters:
1 inhalation and skin contact: TMS-Py may be irritating to the skin and eyes, so avoid inhalation and skin contact during operation.
2. Storage: TMS-Py should be stored in a dry, cool place, and away from fire and oxidant.
3. Waste disposal: do not pour TMS-Py into the sewer or general trash can, should be properly disposed of in accordance with local regulations.
1. Appearance: The TMS-Py is a colorless to light yellow liquid with a special smell.
2. Solubility: TMS-Py dissolves in many organic solvents.
3. Stability: TMS-Py is relatively stable at room temperature, but affected by light and oxygen in the air, it is prone to condensation, oxidation and other reactions.
The main uses of the TMS-Py are as follows:
1. Organic Synthesis Reagents: TMS-Py in organic synthesis as an important reagent. It can be used to synthesize compounds, such as amides, ethyl carboxylates, and so on.
2. Catalyst: TMS-Py, as a ligand of copper, can coordinate with copper ions to form a complex, which has a catalytic effect. In organic synthesis reactions, TMS-Py complexes can be used to catalyze cyclization reactions, substitution reactions of alkyl halides, etc.
There are many methods for preparing TMS-Py, and a common method is as follows:
Benzonitrile is reacted with trimethylsilyl magnesium chloride to obtain dimethylchlorosilicyl phenyl palladium, and then reacted with pyridine to obtain TMS-Py.
When using the TMS-Py, you need to pay attention to the following safety matters:
1 inhalation and skin contact: TMS-Py may be irritating to the skin and eyes, so avoid inhalation and skin contact during operation.
2. Storage: TMS-Py should be stored in a dry, cool place, and away from fire and oxidant.
3. Waste disposal: do not pour TMS-Py into the sewer or general trash can, should be properly disposed of in accordance with local regulations.
Last Update：2024-04-10 22:29:15
