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150726-89-9

Dimethyl 2-(2-methoxyphenoxy)malonate

CAS: 150726-89-9

Molecular Formula: C12H14O6

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150726-89-9 - Names and Identifiers

Name Dimethyl 2-(2-methoxyphenoxy)malonate
Synonyms 2-MethoxyphenoxyMalonate
DIMETHYL (2-METHOXYPHENOXY)MALONATE
Dimethyl (o-Methoxyphenoxy)malonate
Dimethyl 2-(2-methoxyphenoxy)malonate
Dimethyl-2-(2-methoxyphenoxy)malonate
dimethyl (2-methoxyphenoxy)propanedioate
1,3-diMethyl 2-(2-Methoxyphenoxy)propanedioate
2-(2-Methoxyphenoxy)malonic acid dimethyl ester
2-methoxy-2-phenoxypropanedioic acid dimethyl ester
(2-Methoxyphenoxy)-propanedioic Acid Dimethyl Ester
CAS 150726-89-9
EINECS 604-747-9
InChI InChI=1/C12H14O6/c1-15-8-6-4-5-7-9(8)18-10(11(13)16-2)12(14)17-3/h4-7,10H,1-3H3

150726-89-9 - Physico-chemical Properties

Molecular FormulaC12H14O6
Molar Mass254.24
Density1.206±0.06 g/cm3(Predicted)
Boling Point320.5±27.0 °C(Predicted)
Flash Point138.381°C
Solubility Dichloromethane, Methanol
Vapor Presure0mmHg at 25°C
AppearanceSolid
ColorWhite
pKa12.17±0.59(Predicted)
Storage ConditionSealed in dry,Room Temperature
Refractive Index1.497

150726-89-9 - Reference Information

Use dimethyl 2-(2-methoxyphenoxy) malonate is useful as a pharmaceutical synthesis intermediate.
preparation dimethyl 2-(2-methoxyphenoxy) malonate was prepared as follows: 2-methoxyphenol (805.54g, 33.83 mmol) was dissolved in toluene (845.75 mL) at 20-30 °c and sodium hydroxide (g, mmol) was added. The reaction mass was heated to reflux temperature and water was separated azeotropically. Thereafter, dimethyl chloromalonate (147.6g,886.16mmol) was added over 30 minutes at 60-65 °c and heated to reflux temperature and stirred for 3 hours. The reaction mass was cooled to room temperature, washed with DM water, then washed with 1% w / v aqueous sodium hydroxide solution and concentrated to give 195g of the title compound dimethyl 2-(2-methoxyphenoxy) malonate.
Last Update:2024-04-10 22:29:15
150726-89-9
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