147739-88-6
6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine
CAS: 147739-88-6
Molecular Formula: C7H8N2
147739-88-6 - Names and Identifiers
147739-88-6 - Physico-chemical Properties
| Molecular Formula | C7H8N2 |
| Molar Mass | 120.15 |
| Density | 1.114±0.06 g/cm3(Predicted) |
| Boling Point | 215.8±30.0 °C(Predicted) |
| Flash Point | 128.5°C |
| Vapor Presure | 0.00173mmHg at 25°C |
| pKa | 6.68±0.20(Predicted) |
| Storage Condition | 2-8℃ |
147739-88-6 - Reference Information
| application | 6, 7-dihydro-5H-pyrrolo [3,4-b] pyridine Chinese alias 6, 7-dihydro-5H-pyrrolo [3,4,6] pyridine, pyrrolo pyridine ring compound is an important pharmaceutical intermediate, it is mainly used to synthesize moxifloxacin (Moxifloxacin), a new fluoroquinolone drug. At present, the market demand is large and the price is relatively high. Scientists from various countries have done a lot of research on its synthesis. In recent years, the clinical dosage of fluoroquinolones has exceeded that of penicillin. It is low in price, well absorbed, can be taken orally and injected, and can be quickly distributed to various tissues. As a new fluoroquinolone drug, moxifloxacin has received extensive attention from scientists. |
| preparation | using pyridine 2, 3-dicarboxylate as raw material, first esterify to generate dimethyl pyridine dicarboxylate, and then use a mixed reagent composed of sodium borohydride and anhydrous calcium chloride to reduce the corresponding methyl ester. The reaction product can directly carry out the next chlorination reaction without purification. The chlorination product uses acetonitrile as the solvent, using anhydrous potassium carbonate as a base, the cyclization product 6, 7-dihydro-pyrrolo [3, 4-b] pyridine can be obtained by reacting at room temperature. The method has novel design, mild reaction conditions and simple reaction treatment, which is especially suitable for industrialization and enriches the synthesis methods of pyrrolo pyridine ring compounds. 6, 7-dihydro-5H-pyrrolo [3,4-b] pyridine preparation roadmap is as follows: fig. 1 6, 7-dihydro-5H-pyrrolo [3,4-b] pyridine preparation roadmap |
Last Update：2024-04-09 21:04:16
Supplier List
Spot supply
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Request for quotationCAS: 147739-88-6
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Visit Supplier Webpage Request for quotationCAS: 147739-88-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Visit Supplier Webpage Request for quotationCAS: 147739-88-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Visit Supplier Webpage Request for quotation
CAS: 147739-88-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 147739-88-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Request for quotationCAS: 147739-88-6
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Visit Supplier Webpage Request for quotationCAS: 147739-88-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Visit Supplier Webpage Request for quotationCAS: 147739-88-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine Visit Supplier Webpage Request for quotation
CAS: 147739-88-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 147739-88-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History