Molecular Formula | C21H18ClFN6O2 |
Molar Mass | 440.86 |
Density | 1.45±0.1 g/cm3(Predicted) |
Boling Point | 734.6±70.0 °C(Predicted) |
Solubility | DMSO: ≥ 35 mg/mL |
pKa | 14.03±0.10(Predicted) |
Storage Condition | -20℃ |
In vitro study | GDC-0994 effective inhibition of p90RSK in tumor cells. |
In vivo study | GDC-0994 (oral) elicited significant multiple single dose activity in in vitro cancer models, including mice with KRAS mutant and BRAF mutant human xenograft tumors. In vivo, GDC-0994 (orally) inhibits ERK phosphorylation and activation of ERK-mediated signal transduction pathways, subsequently preventing ERK-dependent tumor cell proliferation and survival. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.268 ml | 11.342 ml | 22.683 ml |
5 mM | 0.454 ml | 2.268 ml | 4.537 ml |
10 mM | 0.227 ml | 1.134 ml | 2.268 ml |
5 mM | 0.045 ml | 0.227 ml | 0.454 ml |