1420290-99-8
2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide hydrochloride
CAS: 1420290-99-8
Molecular Formula: C15H14Cl3N3O4
1420290-99-8 - Names and Identifiers
1420290-99-8 - Physico-chemical Properties
| Molecular Formula | C15H14Cl3N3O4 |
| Molar Mass | 406.64836 |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Bioactive HJC0152 hydrochloride is an inhibitor of signal transducer and activator of transcription 3 (STAT3). |
1420290-99-8 - Uses and synthesis methods
Target
STAT3
in vitro studies
HJC0152 hydrochloride (compound 11) significantly inhibits cell proliferation and induces apoptosis accompanying cellular morphological changes at concentrations of 1, 5, and 10 μM. Results show that treatment with 10 μM HJC0152 hydrochloride decreases the STAT3 promoter activity in MDA-MB-231 cells by approximately 32%, and increasing the dose of HJC0152 hydrochloride to 20 μM further decreases STAT3 promoter activity by 62% as compare with control. Total STAT3 is reduced after treatment with HJC0152 hydrochloride. HJC0152 hydrochloride induces cleaved caspase-3 and down regulates cyclin D1 in MDA-MB-231 cells.
In vivo studies
Mice treated with 7.5 mg/kg of HJC0152 hydrochloride (compound 11) via ip show a better effect in inhibiting tumor growth. The growth of xenograft tumors in mice is significantly reduced by HJC0152 hydrochloride at a dose of 25 mg/kg. It is also noteworthy that HJC0152 hydrochloride does not show significant signs of toxicity at a dose of 75 mg/kg.
Last Update：2024-04-09 21:11:58
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