140645-53-0
2-AMINOMETHYL-4-BOC-MORPHOLINE
CAS: 140645-53-0
Molecular Formula: C10H20N2O3
140645-53-0 - Names and Identifiers
140645-53-0 - Physico-chemical Properties
| Molecular Formula | C10H20N2O3 |
| Molar Mass | 216.28 |
| Density | 1.078±0.06 g/cm3(Predicted) |
| Boling Point | 310.7±27.0 °C(Predicted) |
| Flash Point | 141.7°C |
| Vapor Presure | 0.000589mmHg at 25°C |
| pKa | 9.37±0.29(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.477 |
140645-53-0 - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN2811 |
| Hazard Note | Irritant |
140645-53-0 - Introduction
4-Boc-2-(aminomethyl) morpholine, full name N-Boc-N-methylglycinol, is an organic compound with the following properties and uses:
Nature:
1. Appearance: 4-Boc-2-(aminomethyl) morpholine is a white crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide and dichloromethane.
3. molecular structure: the molecular formula is C10H19NO3, the relative molecular mass is 201.26g/mol.
Use:
1. 4-Boc-2-(aminomethyl) morpholine is commonly used as an intermediate in organic synthesis, especially as a removal agent of the protecting group of the compound in the deprotection reaction. It is also used to synthesize drugs and natural products containing N-Boc-N-methylglycinol structures.
3. Sometimes it can also be used as a building block for stereoreceptors (chiral sensors) or ligands (ligands).
Preparation Method:
The method of preparing 4-Boc-2-(aminomethyl) morpholine can be carried out by the following steps:
1. First, chloromethyl morpholine is subjected to a condensation reaction with N-Boc-glycine ester to generate chloromethyl-N-Boc-N-methylglycinol.
2. Next, the product is subjected to condensation reaction with excess sodium carbonate to produce 4-Boc-2-(aminomethyl) morpholine.
3. Finally, the target product is obtained by crystallization or other appropriate purification methods.
Safety Information:
1. 4-Boc-2-(aminomethyl) morpholine is not significantly hazardous under normal conditions of use.
2. in the process of operation, should follow the safety procedures, such as wearing appropriate protective equipment (such as gloves, goggles).
3. This compound may be irritating to the eyes, skin and respiratory system. Avoid contact and inhalation.
4. During storage and handling, it should be stored in a closed container, away from fire and oxidant.
Nature:
1. Appearance: 4-Boc-2-(aminomethyl) morpholine is a white crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide and dichloromethane.
3. molecular structure: the molecular formula is C10H19NO3, the relative molecular mass is 201.26g/mol.
Use:
1. 4-Boc-2-(aminomethyl) morpholine is commonly used as an intermediate in organic synthesis, especially as a removal agent of the protecting group of the compound in the deprotection reaction. It is also used to synthesize drugs and natural products containing N-Boc-N-methylglycinol structures.
3. Sometimes it can also be used as a building block for stereoreceptors (chiral sensors) or ligands (ligands).
Preparation Method:
The method of preparing 4-Boc-2-(aminomethyl) morpholine can be carried out by the following steps:
1. First, chloromethyl morpholine is subjected to a condensation reaction with N-Boc-glycine ester to generate chloromethyl-N-Boc-N-methylglycinol.
2. Next, the product is subjected to condensation reaction with excess sodium carbonate to produce 4-Boc-2-(aminomethyl) morpholine.
3. Finally, the target product is obtained by crystallization or other appropriate purification methods.
Safety Information:
1. 4-Boc-2-(aminomethyl) morpholine is not significantly hazardous under normal conditions of use.
2. in the process of operation, should follow the safety procedures, such as wearing appropriate protective equipment (such as gloves, goggles).
3. This compound may be irritating to the eyes, skin and respiratory system. Avoid contact and inhalation.
4. During storage and handling, it should be stored in a closed container, away from fire and oxidant.
Last Update：2024-04-09 21:01:54
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View History
140645-53-0
4215-95-6
TSU-68 (SU6668)
41483-43-6
2456306-61-7
氨乙基亚磺酸
Sodium n-amylxanthate
Magnesium dibromide hexahydrate
4-氧代戊酸 钙盐
4215-95-6
TSU-68 (SU6668)
41483-43-6
2456306-61-7
氨乙基亚磺酸
Sodium n-amylxanthate
Magnesium dibromide hexahydrate
4-氧代戊酸 钙盐