138108-72-2

138108-72-2 - Names and Identifiers

Name	(R)-3-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl ester
Synonyms	(R)-N-BOC-PYRROLIDINE-3-METHANOL (R)-N-BOC-pyrrolidine-3-METHANOL (R)-1-Boc-3-hydroxymethylpyrrolidine (R)-1-Boc-3-(hydroxymethyl)pyrrolidine (R)-1-tert-Butoxycarbonylpyrrolidine-3-methanol (R)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate tert-butyl (3R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate tert-butyl (3R)-3-(hydroxyMethyl)pyrrolidine-1-carboxylate 3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3(R)-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl ester (R)-3-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl ester (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (3R)-3-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
CAS	138108-72-2
EINECS	1592732-453-0
InChI	InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1

138108-72-2 - Physico-chemical Properties

Molecular Formula	C10H19NO3
Molar Mass	201.26
Density	1.089
Boling Point	289.5±13.0 °C(Predicted)
Flash Point	128.9°C
Water Solubility	Slightly soluble in water
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.000241mmHg at 25°C
Appearance	Oil
Color	Clear Colourless to Pale Yellow Thick
pKa	14.93±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.483

138108-72-2 - Introduction

(R)-1-Boc-3-hydroxymethylpyrrolidine is an organic compound having the formula C12H22N2O3.

This compound is a white solid with a high melting and boiling point. It is stable at normal temperature and soluble in organic solvents such as chloroform and dimethylformamide.

(R)-1-Boc-3-hydroxymethylpyrrolidine is commonly used as an intermediate in drug synthesis and can be used to synthesize other compounds or drugs. As the source of the hydroxymethyl protecting group, it can protect the hydroxyl group to prevent unnecessary reactions, and it is reversible to facilitate the subsequent reaction operation.

The compound can be prepared by reacting pyrrolidine with hydrofluoric acid to obtain (R)-1-Boc-3-hydroxymethylpyrrolidine.

When using and handling this compound, you need to pay attention to safety. It can cause irritation to the eyes, skin and respiratory tract, so wear appropriate protective equipment such as glasses and gloves. In addition, it should be operated in a well-ventilated place to avoid inhaling its gas or dust. When exposed to this compound, wash the affected area thoroughly with soap and water.

Last Update：2024-04-09 20:52:54