135-87-5
1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride
CAS: 135-87-5
Molecular Formula: C14H20ClNO2
135-87-5 - Names and Identifiers
135-87-5 - Physico-chemical Properties
| Molecular Formula | C14H20ClNO2 |
| Molar Mass | 269.7671 |
| Melting Point | 229-231 °C |
| Appearance | Solid |
| Storage Condition | Ventilation and low temperature drying |
| In vitro study | When the medulla is superfused with α 2 adrenoceptor antagonist Piperoxane (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition. |
135-87-5 - Risk and Safety
| Toxicity | LD50 oral in mouse: 502mg/kg |
135-87-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.707 ml | 18.535 ml | 37.069 ml |
| 5 mM | 0.741 ml | 3.707 ml | 7.414 ml |
| 10 mM | 0.371 ml | 1.853 ml | 3.707 ml |
| 5 mM | 0.074 ml | 0.371 ml | 0.741 ml |
Last Update：2024-01-02 23:10:35
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