132-20-7
pheniramine maleate
CAS: 132-20-7
Molecular Formula: C20H24N2O4
132-20-7 - Names and Identifiers
| Name | pheniramine maleate |
| Synonyms | pm241 inhiston Pheniramine maleate pheniramine maleate PHENIRAMINE MALEATE PHENIRAMINE MALEATE SALT PROPHENPYRIDAMINE MALEATE pheniraminehydrogenmaleate pheniramine hydrogen maleate phenyl(2-pyridyl)(beta-n,n-dimethylaminomethyl)methanemaleate 2-[3-(dimethylammonio)-1-phenylpropyl]pyridinium propanedioate 2-[3-(dimethylammonio)-1-phenylpropyl]pyridinium (2E)-but-2-enedioate N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate |
| CAS | 132-20-7 |
| EINECS | 205-051-4 |
| InChI | InChI=1/C16H20N2.C3H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;4-2(5)1-3(6)7/h3-10,12,15H,11,13H2,1-2H3;1H2,(H,4,5)(H,6,7) |
132-20-7 - Physico-chemical Properties
| Molecular Formula | C20H24N2O4 |
| Molar Mass | 356.42 |
| Density | 1.2233 (rough estimate) |
| Melting Point | 104-108°C |
| Boling Point | 489.25°C (rough estimate) |
| Flash Point | 164.5°C |
| Water Solubility | >=1 g/100 mL at 24 ºC |
| Solubility | Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| Vapor Presure | 5.07E-05mmHg at 25°C |
| Appearance | neat |
| Color | White |
| Maximum wavelength(λmax) | 262nm(lit.) |
| Merck | 14,7235 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.6800 (estimate) |
| In vitro study | Pheniramine Maleate is a histamine H1 antagonist with no sedative effect. It is used to treat pollinosis, rhinitis, allergic skin diseases, and pruritus. Pheniramine acts on the histamine H1 receptor site on the cell in competition with histamine to produce an effect. Antihistamines antagonize the pharmacological effects of histamine by activating H1 receptor-mediated sites, thereby reducing the intensity of allergic reactions and responses to tissue damage. Antihistamines inhibit histamine-induced vesicular (swelling) and flare (vasodilation) responses by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelial cells and mast cells. They act on the H1-receptor and effectively exert a competitive antagonistic action against histamine. |
132-20-7 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | UT0175000 |
| HS Code | 2933399090 |
132-20-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.806 ml | 14.028 ml | 28.057 ml |
| 5 mM | 0.561 ml | 2.806 ml | 5.611 ml |
| 10 mM | 0.281 ml | 1.403 ml | 2.806 ml |
| 5 mM | 0.056 ml | 0.281 ml | 0.561 ml |
Last Update：2024-01-02 23:10:35
132-20-7 - Reference Information
| use | pheniramine maleate is a white crystalline powder, which is used for colds and allergic diseases of skin and mucous membrane, and has good effect on allergic diseases of eyes. It is also used for vomiting caused by fainting. |
| biological activity | Pheniramine Maleate is an antihistamine with anticholinergic properties and is used to treat allergic diseases such as hay fever or urticaria. |
| in vitro study | Pheniramine Maleate is a histamine H1 antagonist with no sedative effect. It is used to treat hay, rhinitis, allergic skin diseases, and pruritus. Histamine H1 receptor sites Pheniramine acting on cells compete with histamine to produce effects. Antihistamines antagonize the pharmacological effects of histamine by activating H1 receptor-mediated sites, thereby reducing the intensity of allergic reactions and the response to tissue damage. Antihistamines inhibit histamine-induced blister (swelling) and flare (vasodilation) responses by blocking the binding of histamine to its receptors to nerves, vascular smooth muscle, glandular cells, endothelial cells, and mast cells. They act on H1-receptors and effectively play a competitive role in antagonizing histamine. |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-09 02:00:03
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