130115-85-4
2-Chloro-3-Bromo-5-Hydroxypyridine
CAS: 130115-85-4
Molecular Formula: C5H3BrClNO
130115-85-4 - Names and Identifiers
| Name | 2-Chloro-3-Bromo-5-Hydroxypyridine |
| Synonyms | 5-Bromo-6-chL oropyridin-3-oL 5-bromo-6-chloropyridin-3-ol 3-Pyridinol,5-bromo-6-chloro- 2-Chloro-3-Bromo-5-Hydroxypyridine |
| CAS | 130115-85-4 |
| InChI | InChI=1/C5H3BrClNO/c6-4-1-3(9)2-8-5(4)7/h1-2,9H |
130115-85-4 - Physico-chemical Properties
| Molecular Formula | C5H3BrClNO |
| Molar Mass | 208.44 |
| Density | 1.908±0.06 g/cm3(Predicted) |
| Boling Point | 388.6±37.0 °C(Predicted) |
| Flash Point | 188.824°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 7.91±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.629 |
130115-85-4 - Risk and Safety
| Hazard Class | IRRITANT |
130115-85-4 - Introduction
2-Chloro-3-bromo-5-hydroxypyridine is an organic compound with the chemical formula C5H3BrClNO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Chloro-3-bromo-5-hydroxypyridine is a colorless to pale yellow crystalline solid.
-Solubility: It is soluble in organic solvents such as chloroform and acetone, and slightly soluble in water.
-Melting point: Its melting point is about 112-115°C.
-Stability: It is relatively stable at room temperature, but it is easy to decompose and degrade under conditions such as heat, light and oxidation.
Use:
-As a chemical synthesis intermediate: 2-chloro-3-bromo-5-hydroxypyridine can be used to synthesize other organic compounds, such as drugs, pesticides and dyes.
-As a pharmaceutical research reagent: It is also used as a reagent for the preparation, research and development of new drugs.
Preparation Method:
A common and feasible preparation method is as follows:
1. hydrogen chloride or sodium hydroxide reacts with pyridine to give 2-chloropyridine.
2. In an inert gas atmosphere, 2-chloropyridine reacts with bromine to generate 2-chloro-3-bromopyridine.
3. Finally, under alkaline conditions, 2-chloro-3-bromopyridine reacts with sodium hydroxide to generate 2-chloro-3-bromo-5-hydroxypyridine.
Safety Information:
-2-Chloro-3-bromo-5-hydroxypyridine is an organic compound and should be operated under specialized laboratory conditions.
-Avoid contact with strong oxidants and strong acids to avoid dangerous reactions.
-Observe personal protective measures during use, such as wearing protective glasses and gloves to ensure good ventilation.
-Avoid inhalation, contact with skin and ingestion.
-In case of inadvertent contact, flush the affected area quickly with plenty of water and seek medical advice.
Nature:
-Appearance: 2-Chloro-3-bromo-5-hydroxypyridine is a colorless to pale yellow crystalline solid.
-Solubility: It is soluble in organic solvents such as chloroform and acetone, and slightly soluble in water.
-Melting point: Its melting point is about 112-115°C.
-Stability: It is relatively stable at room temperature, but it is easy to decompose and degrade under conditions such as heat, light and oxidation.
Use:
-As a chemical synthesis intermediate: 2-chloro-3-bromo-5-hydroxypyridine can be used to synthesize other organic compounds, such as drugs, pesticides and dyes.
-As a pharmaceutical research reagent: It is also used as a reagent for the preparation, research and development of new drugs.
Preparation Method:
A common and feasible preparation method is as follows:
1. hydrogen chloride or sodium hydroxide reacts with pyridine to give 2-chloropyridine.
2. In an inert gas atmosphere, 2-chloropyridine reacts with bromine to generate 2-chloro-3-bromopyridine.
3. Finally, under alkaline conditions, 2-chloro-3-bromopyridine reacts with sodium hydroxide to generate 2-chloro-3-bromo-5-hydroxypyridine.
Safety Information:
-2-Chloro-3-bromo-5-hydroxypyridine is an organic compound and should be operated under specialized laboratory conditions.
-Avoid contact with strong oxidants and strong acids to avoid dangerous reactions.
-Observe personal protective measures during use, such as wearing protective glasses and gloves to ensure good ventilation.
-Avoid inhalation, contact with skin and ingestion.
-In case of inadvertent contact, flush the affected area quickly with plenty of water and seek medical advice.
Last Update：2024-04-09 21:00:56
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View History
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