127956-11-0
4-Oxotetrahydropyran-3-carboxylic acid methyl ester
CAS: 127956-11-0
Molecular Formula: C7H10O4
127956-11-0 - Names and Identifiers
127956-11-0 - Physico-chemical Properties
| Molecular Formula | C7H10O4 |
| Molar Mass | 158.15 |
| Density | 1.201±0.06 g/cm3(Predicted) |
| Boling Point | 236.4±30.0 °C(Predicted) |
| pKa | 10.61±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
127956-11-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 6.323 ml | 31.615 ml | 63.23 ml |
| 5 mM | 1.265 ml | 6.323 ml | 12.646 ml |
| 10 mM | 0.632 ml | 3.162 ml | 6.323 ml |
| 5 mM | 0.126 ml | 0.632 ml | 1.265 ml |
Last Update：2024-01-02 23:10:35
127956-11-0 - Reference Information
| Introduction | methyl 4-oxotetrahydro-2h-pyran-3-carboxylate due to the presence of conjugated double bonds and ester groups, tetrahydropyrone derivatives are important intermediates in organic synthesis. In organic synthesis, tetrahydropyrone can be used as a Diene body to react Diels-Alder with alkyne, ENE, etc. In particular, in recent years, asymmetric Diels-Alder reactions of tetrahydropyrone with various Dienes catalyzed by chiral organic bases and the synthesis of natural products using tetrahydropyrone as a precursor material, further enriched the tetrahydropyrone chemistry. |
| Use | methyl 4-oxotetrahydro-2h-pyran-3-carboxylate is a carboxylic acid ester derivative, it can be used as pharmaceutical and chemical intermediates. |
| synthesis method | take a clean three-mouth reaction bottle, start the stirring device, add tetrahydropyrone, dichloromethane solution, triethylamine was added to the methanol-dichloromethane solution of tetrahydropyrone, and a dichloromethane solution of dimethyl carbonate was added dropwise. After dropping, the system was heated to 50 ° C., and the cooling reflux device was started. Reaction 15 hours, thin layer chromatography to detect the progress of the reaction. At the end of the reaction, the oil bath was removed, the solvent was distilled off under reduced pressure, and the concentrate was chromatographed on a silica gel column [eluent: V (ethyl acetate)/V (petroleum ether)]. = 1/10] The compound 4-oxotetrahydro-2h-pyran-3-carboxylic acid methyl ester was purified. |
Last Update：2024-04-09 21:01:54
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View History
127956-11-0
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126752-51-0
吩嗪硫酸甲酯
2 樟脑磺酸氯吡格雷
octane,2-methyl-
N-Acetylpiperidone
3-fluoro-2-methylbenzaldehyde
Terbium(III) acetate hexahydrate
N-OCTYLTIN-TRICHLORIDE
3b-hydroxy-5-pregnen-20-one